Abstract
NADP-malic enzyme (NADP-ME) (E.C. 1.1.1.40) is situated in the cytosol of Drosophila melanogaster. Both the tissue activity and CRM level of NADP-ME parallel changes in the dosage of a gene, Men +, located in region 87C2-3 to 87D1-2 of the third chromosome. The tissue activity of NADP-ME is very high in early third instar larvae, providing about 33% of the NADPH at this life stage. The tissue activity declines during pupal development but increases as the adult ages. The concentration of NADP-ME CRM and tissue activity are coordinately increased in third instar larvae by dietary carbohydrate and decreased by dietary lipid.
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This work was supported by National Research Council of Canada Grant No. A5860 and by the University of Calgary Research Policy and Grants Committee.
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Geer, B.W., Krochko, D. & Williamson, J.H. Ontogeny, cell distribution, and the physiological role of NADP-malic enzyme in Drosophila melanogaster . Biochem Genet 17, 867–879 (1979). https://doi.org/10.1007/BF00504309
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DOI: https://doi.org/10.1007/BF00504309