Summary
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1.
The tetradecapeptide bombesin was tested for its activity on the stomach in rats, dogs and men. On the rat stomach bombesin displayed a striking spasmogenic activity apparently independent from the autonomic nervous system.
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2.
In the dog the peptide was spasmogenic on the denervated Heidenhain pouch and the antrum. The inhibitory activity predominated on the innervated stomach and body fundus.
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3.
In man the peptide exerted a contracting effect on the antrum and the pylorus and an inhibitory effect on the stomach body and the fundus. In vitro studies performed on human stomach isolated strips showed a constant stimulant effect.
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4.
Apparently bombesin has a direct effect on the in situ rat stomach and on the isolated preparations, whereas it has an indirect effect on the other in situ innervated preparations.
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This work was supported by a grant from the C. N. R. Rome.
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Bertaccini, G., Impicciatore, M. Action of bombesin on the motility of the stomach. Naunyn-Schmiedeberg's Arch. Pharmacol. 289, 149–156 (1975). https://doi.org/10.1007/BF00501302
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DOI: https://doi.org/10.1007/BF00501302