Summary
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1.
The phagocytic activity of the reticulo-endothelial system in mice (carbon-clearance test) is depressed after intravenous injection of Cu-chlorophyllin. Both extent and duration of this reduction are dose-dependent and followed by a stimulation. The weights of liver and spleen are unchanged.
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2.
Cu-chlorophyllin depresses the endotoxin (1 μg/kg i.v.) stimulated RES too. The first peak 3 h after endotoxin application is more affected by Cu-chlorophyllin than the second one, which is accompanied by an increased weight of the spleen.
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3.
The carbon-suspension itself, which is used during the carbon-clearance test, stimulates the phagocytic activity from 8 h until 8 days. It increases the weight of the liver and spleen.
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4.
From these results it is concluded that the reduction in phagocytic activity is due to a specific direct action of Cu-chlorophyllin on the phagocyting cells.
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Literatur
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Garbe, G., Cold, N. & Friedberg, K.D. Beeinflussung des reticulo-endothelialen Systems durch Chlorophyllin. Naunyn-Schmiedeberg's Arch. Pharmacol. 272, 289–296 (1972). https://doi.org/10.1007/BF00499040
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DOI: https://doi.org/10.1007/BF00499040