Summary
The renal effects of histamine, histamine receptor agonists and antagonists were studied in the isolated rat kidney, which was perfused with a synthetic medium at constant perfusion pressure in a single pass system.
Histamine induced a concentration-dependent increase of renin release ranging from a two-fold increase at 0.5 μM to a four-fold increase at 10 μM. No change in renal vascular resistance, glomerular filtration rate and sodium excretion occurred. Histamine-H2-antagonists (ranitidine and cimetidine) were more effective to block the response to histamine than was the histamine H1-antagonist diphenhydramine.
Histamine-H2-agonists (impromidine and dimaprit, 2.5 μM each) were potent stimulators of renin release, their effect was blunted by H2-antagonists.
The histamine-H1-agonist pyridyl-2-ethylamine had a low stimulatory activity at 10 μM final concentration, which may reflect partial H2-agonistic effects.
It is concluded that histamine stimulates renin release via H2-receptor activation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Angus JA, Korner PI (1977) Regional vascular resistance and heart rate responses mediated through H1-and H2-histamine receptors in the unanaesthetised rabbit. Eur J of Pharmacol 45: 45–53
Campbell WB, Itskovits HD (1976) Effect of histamine and antihistamine on renal hemodynamics and function in the isolated perfused canine kidney. J Pharmacol Exp Ther 198: 661–667
Ercan ZS, Türk RK (1975) Potentiation of the effect of histamine by PGE in the isolated perfused rabbit kidney and guinea pig lung. Experientia 31: 333–335
Green JP, Hough IB (1980) Histamine receptors. In: Schulster D, Levitzki A (eds) Cellular receptors and neurotransmitter. John Wiley & Sons Ltd London, pp 288–305
Green JP, Johnson CL, Weinstein H, Maayani S (1977) Antagonism of histamine-activated adenylate cyclase in brain of d-lysergic acid diethylamide. Proc Natl Acad Sci USA Vol 74 No 12: 5697–5701
Hirschowitz BJ (1979) H2-histamine receptors. Ann Rev Pharmacol Toxicol 19: 203–244
Juan H, Sametz W (1980) Histamine-induced release of arachidonic acid and of prostaglandins in the peripheral vascular bed. Mode of action. Naunyn-Schmiedeberg's Arch Pharmacol 314: 183–190
McNeill JH (1979) Histamine receptors and cyclic AMP. Can J Physiol Pharmacol 58: 1023–1030
Polanin A, McNeill JH (1980) The effect of theophylline on histamine H1- and H2-receptor mediated responses in rabbit atria. Can J Physiol Pharmacol 59: 25–30
Schwertschlag U, Grunewald R, Hackenthal E (1979) Prostglandins and renin release from the isolated perfused rat kidney. Naunyn-Schmiedeberg's Arch Pharmacol 307: R37
Schwertschlag U, Seyberth HW, Müller H, Grunewald R, Erlenmaier T, Rohs HG, Hackenthal E (1980) Intrarenal conversion of prostaglandin F2 to prostaglandin E2 and renin release in the isolated perfused rat kidney. Clin Sci 59: 117s-119s
Slegers JFG, Förster MIG (1980) Absence of effect of diazoxide on sodium and water handling in the isolated perfused rat kidney. Arch Int Pharmacodyn Ther 244 (2): 309–320
Sperk G, Ratzenhofer E, Simbrunner G, Coradello H, Pollak, A, Lubec G (1980) Evidence for H2-receptor activity on glomerular cells: The glomerular basement membrane. In: Lubec G (ed) 1st Int Symp Vienna. Renal Physiol. Karger, Basel
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schwertschlag, U., Hackenthal, E. Histamine stimulates renin release from the isolated perfused rat kidney. Naunyn-Schmiedeberg's Arch. Pharmacol. 319, 239–242 (1982). https://doi.org/10.1007/BF00495872
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00495872