Summary
The occurrence and distribution of neurotensin-immunoreactive (NT-IR) perikarya was studied in the central nervous system of the guinea pig using a newly raised antibody (KN 1). Numerous NT-IR perikarya were found in the nuclei amygdaloidei, nuclei septi interventriculare, hypothalamus, nucleus parafascicularis thalami, substantia grisea centralis mesencephali, ventral medulla oblongata, nucleus solitarius and spinal cord. The distribution of NT-IR perikarya was similar to that previously described in the rat and monkey. In the gyrus cinguli, hippocampus and nucleus olfactorius, though, no NT-IR neurons were detected in this investigation. Additional immunoreactive perikarya, however, were observed in areas of the ventral medulla oblongata, namely in the nucleus paragigantocellularis, nucleus retrofacialis and nucleus raphe obscurus.
The relevance of the NT-IR perikarya within the ventral medulla oblongata is discussed with respect to other neuropeptides, which are found in this area, and to cardiovascular regulation.
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Abbreviations
- abl:
-
nucleus amygdaloideus basalis lateralis
- abm:
-
nucleus amygdaloideus basalis medialis
- acc:
-
nucleus amygdaloideus centralis
- aco:
-
nucleus amygdaloideus corticalis
- ahp:
-
area posterior hypothalami
- ala:
-
nucleus amygdaloideus lateralis anterior
- alp:
-
nucleus amygdaloideus lateralis posterior
- ame:
-
nucleus amygdaloideus medialis
- atv:
-
area tegmentalis ventralis
- bst:
-
nucleus proprius striae terminalis
- CA:
-
commissura anterior
- CC:
-
corpus callosum
- cgld:
-
corpus geniculatum laterale dorsale
- cglv:
-
corpus geniculatum laterale ventrale
- cgm:
-
corpus geniculatum mediale
- CHO:
-
chiasma opticum
- CI:
-
capsula interna
- co:
-
nucleus commissuralis
- cod:
-
nucleus cochlearis dorsalis
- cp:
-
nucleus caudatus/Putamen
- cs:
-
colliculus superior
- cu:
-
nucleus cuneatus
- dmh:
-
nucleus dorsomedialis hypothalami
- DP:
-
decussatio pyramidum
- em:
-
eminentia mediana
- ent:
-
cortex entorhinalis
- epi:
-
epiphysis
- FLM:
-
fasciculus longitudinalis medialis
- fm:
-
nucleus paraventricularis hypothalami pars filiformis
- FX:
-
fornix
- gd:
-
gyrus dentatus
- gp:
-
globus pallidus
- gr:
-
nucleus gracilis
- hl:
-
nucleus habenulae lateralis
- hm:
-
nucleus habenulae medialis
- hpe:
-
hippocampus
- ift:
-
nucleus infratrigeminalis
- io:
-
oliva inferior
- ip:
-
nucleus interpeduncularis
- LM:
-
lemniscus medialis
- MT:
-
tractus mamillo-thalamicus
- na:
-
nucleus arcuatus
- nls:
-
nucleus lateralis septi
- nms:
-
nucleus medialis septi
- npca:
-
nucleus proprius commissurae anterioris
- ns:
-
nucleus solitarius
- n III:
-
nucleus nervi oculomotorii
- nt V:
-
nucleus tractus spinalis nervi trigemini
- ntm:
-
nucleus mesencephalicus nervi trigemini
- osc:
-
organum subcommissurale
- P:
-
tractus cortico-spinalis
- PC:
-
pedunculus cerebri
- PCI:
-
pedunculus cerebellaris inferior
- pir:
-
cortex piriformis
- pol:
-
area praeoptica lateralis
- pom:
-
area praeoptica medialis
- prt:
-
area praetectalis
- pt:
-
nucleus parataenialis
- pvh:
-
nucleus paraventricularis hypothalami
- pvt:
-
nucleus paraventricularis thalami
- r:
-
nucleus ruber
- re:
-
nucleus reuniens
- rgi:
-
nucleus reticularis gigantocellularis
- rl:
-
nucleus reticularis lateralis
- rm:
-
nucleus raphe magnus
- ro:
-
nucleus raphe obscurus
- rp:
-
nucleus raphe pallidus
- rpc:
-
nucleus reticularis parvocellularis
- rpgc:
-
nucleus reticularis paragigantocellularis
- sch:
-
nucleus suprachiasmaticus
- SM:
-
stria medullaris thalami
- snc:
-
substantia nigra compacta
- snl:
-
substantia nigra lateralis
- snr:
-
substantia nigra reticularis
- ST:
-
stria terminalis
- tad:
-
nucleus anterior dorsalis thalami
- tam:
-
nucleus anterior medialis thalami
- tav:
-
nucleus anterior ventralis thalami
- tbl:
-
nucleus tuberolateralis
- tc:
-
nucleus centralis thalami
- tl:
-
nucleus lateralis thalami
- tmd:
-
nucleus medialis dorsalis thalami
- TO:
-
tractus opticus
- TOL:
-
tractus olfactorium lateralis
- tpo:
-
nucleus posterior thalami
- tr:
-
nucleus reticularis thalami
- trs:
-
nucleus triangularis septi
- TS:
-
tractus solitarius
- TS V:
-
tractus spinalis nervi trigemini
- tvl:
-
nucleus ventrolateralis thalami
- vmh:
-
nucleus ventromedialis hypothalami
- vh:
-
ventral horn, Columna anterior
- zi:
-
zona incerta
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Supported by the Deutsche Forschungsgesellschaft (DFG) SFB 90, Carvas
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Triepel, J., Mader, J., Weindl, A. et al. Distribution of NT-IR perikarya in the brain of the guinea pig with special reference to cardiovascular centers in the medulla oblongata. Histochemistry 81, 509–516 (1984). https://doi.org/10.1007/BF00489528
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DOI: https://doi.org/10.1007/BF00489528