Abstract
2-Aminothiazoles and 2-aminobenzothiazoles react with β-chlorovinyl ketones in the presence of acid in two directions to form isomeric thiazolo[3,2-a]pyrimidinium compounds. In the absence of acid, the aminothiazole is alkylated only at the cyclic nitrogen atom without closing of the pyrimidine ring. The PMR spectra were used to establish the structures of the reaction products and to determine the ratios of isomers formed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 632–636, May, 1972.
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Shul'ga, S.I., Chuiguk, V.A. Condensation of 2-aminothiazoles and 2-aminobenzothiazoles and their salts with β-chlorovinyl ketones. Chem Heterocycl Compd 8, 571–575 (1972). https://doi.org/10.1007/BF00488147
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DOI: https://doi.org/10.1007/BF00488147