Abstract
A number of new 1-aryloxy-5-methyl-1,2,3,6-tetrahydro-1,2,6-phosphadiazine-1,3-diones were obtained from arylphosphoric acid dichlorides through the corresponding diamidophosphoric acid esters. Conversion of the 1-phenoxy and 1-ethoxy derivatives to 6-methyl-4-hydroxypyrimidine under Vilsmeierformylation conditions was observed. These compounds were thionated to give the corresponding 1,3-dithiones; the 1-phenoxy derivative was subsequently methylated in the 6 position and animated to give the phosphorus-containing analog of 6-methyl-2-thiocytosine. The bromination of the 1-ethoxy compound and replacement of the bromine by a secondary amine residue were studied.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 972–976, July, 1978.
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Levi, I.S., Garaeva, L.D., Osipova, É.M. et al. 1,2,6-Phosphadiazine-1,3-dione derivatives. Chem Heterocycl Compd 14, 784–788 (1978). https://doi.org/10.1007/BF00471654
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DOI: https://doi.org/10.1007/BF00471654