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Histopathology of experimental Aspergillus fumigatus keratitis

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Abstract

Histopathological studies in rabbit's eyes, 7 and 14 days after intracorneal inoculation with 1×105 Aspergillus fumigatus conidia have been performed.

Similar lesions were found in both periods with fungal hyphae in the anterior third of corneal stroma, round cell infiltration from the sclero-corneal edge and in the anterior chamber and, neovascularization.

No lesions were found in the Descemet's membrane.

Gomori silver-methenamine stain with hematoxiline-eosine counter-stain was found to be the most reliable stain to detect fungal presence in corneal stroma, and Masson's trichromic stain in the study of pathological changes in ocular elements.

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Fons, A., García-de-Lomas, J., Nogueira, J.M. et al. Histopathology of experimental Aspergillus fumigatus keratitis. Mycopathologia 101, 129–131 (1988). https://doi.org/10.1007/BF00437029

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  • DOI: https://doi.org/10.1007/BF00437029

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