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Application of orthogonal functions to the determination of dihydrocodeine in presence of noscapine

Anwendung von Orthogonalfunktionen auf die Bestimmung von Dihydrocodein in Gegenwart von Noscapin

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Summary

The orthogonal function method is applied to the determination of dihydrocodeine bitartrate as a minor component (5 mg) in presence of noscapine hydrochloride (25 mg) without separation. Another method based upon precipitating noscapine by a saturated solution of sodium acetate is also presented. Dihydrocodeine is determined in the filtrate using the orthogonal function method to correct for the unprecipitated fraction of noscapine. Standard deviation is 1.56 and 0.66 for direct and precipitation methods, respectively.

Zusammenfassung

Die direkte photometrische Bestimmung von Dihydrocodeinbitartrat (5 mg) neben der Hauptkomponente Noscapin (Narcotin)-hydrochlorid (25 mg) ohne Abtrennung gelingt, wenn zur Auswertung Orthogonalpolynome herangezogen werden. Eine andere Methode basiert auf der Fällung der Noscapinbase mit gesättigter Natriumacetatlösung. Auch in diesem Fall wird das Dihydrocodein über Orthogonalfunktionen bestimmt, um den Restanteil von Noscapin zu eliminieren und eventuell störende unspezifische Untergrundabsorptionen auszuschließen. Die Standardabweichung beträgt 1,56 ohne Abtrennung und 0,66 bei Fällung des Noscapins.

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Authors and Affiliations

  1. Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt

    A. M. Wahbi & S. Ebel

  2. Abteilung Analytische Chemie, Fachbereich Pharmazie und Lebensmittelchemie der Philipps-Universität Marburg, BRD

    A. M. Wahbi & S. Ebel

Authors
  1. A. M. Wahbi
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  2. S. Ebel
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Wahbi, A.M., Ebel, S. Application of orthogonal functions to the determination of dihydrocodeine in presence of noscapine. Z. Anal. Chem. 270, 282–285 (1974). https://doi.org/10.1007/BF00431327

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  • DOI: https://doi.org/10.1007/BF00431327

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