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The effect of iproniazid and tranylcypromine studied with a dark-avoidance conditioned schedule

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Abstract

Different groups of rats were first trained with a dark avoidance conditioned schedule of the shuttle-box technique. Subsequently different doses of iproniazid and tranylcypromine were injected i.p. and their effects upon the levels of conditioning were measured according to a specific time-table, different for the two drugs.

While iproniazid, at doses of 25.50 and 100 mg/kg almost always induced a decrease of the percentage of the conditioned responses, tranylcypromine, at doses of 2.5 and 5 mg/kg, caused a marked increase of the same, 5 h after its administration.

Such percentage increase of the C.A.R. seems to be temporally related to the marked increase of brain nor-epinephrine induced by this latter drug, also 5 h after its administration.

A comparative study between tranylcypromine and d-amphetamine shows the advantages of this particular type of schedule to distinguish between different classes of central nervous system stimulating drugs.

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Authors and Affiliations

  1. Laboratory of Psychobiology and Psychopharmacology, Rome, Italy

    Luigi Bucci & Daniel Bovet

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  1. Luigi Bucci
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  2. Daniel Bovet
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Bucci, L., Bovet, D. The effect of iproniazid and tranylcypromine studied with a dark-avoidance conditioned schedule. Psychopharmacologia 35, 179–188 (1974). https://doi.org/10.1007/BF00429584

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  • DOI: https://doi.org/10.1007/BF00429584

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