Abstract
Rats were pretreated with methylscopolamine. One group received neostigmine or physostigmine followed by methylphenidate. Physostigmine, but not neostigmine prevented the occurrence of stereotyped gnawing behavior. Another group received methylphenidate followed by physostigmine or neostigmine. Physostigmine abolished rat stereotyped gnawing behavior.
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References
Arnfred, T., Randrup, A.: Cholinergic mechanisms in brain inhibiting amphetamine-induced stereotyped behavior. Acta pharmacol. (Kbh.) 26, 384–394 (1968).
Bogdanski, D. F., Sulser, F., Brodie, B. B.: Comparative action of reserpine, tetrabenazine and chlorpromazine on central parasympathetic activity: Effects on pupillary size and lacrimation in rabbit and on salivation in dog. J. Pharmacol. exp. Ther. 132, 176–182 (1961).
Carlton, P. L.: Cholinergic mechanisms in the control of behavior. Psychological Rev. 20, 19–39 (1963).
Ferris, R. M., Tang, F., Maxwell, R. A.: A comparison of the capacity of isomers of amphetamine, deoxypipradiol, and methylphenidate to inhibit the uptake of tritiated catecholamines into rat cerebral cortex slices, synaptosonal preparations of rat cerebral cortex, hypothalamines and striatum and into adrenergic nerves of rabbit aorta. J. pharmacol. exp. Ther. (in press) (1972).
Goodman, L. S., Gilman, S.: The pharmacologic basis of therapeutics, 4th Ed. New York: MacMillan 1971.
Janowsky, D. S., El-Yousef, M. K., Davis, J. M.: The elicitation of psychotic symptomatology by methylphenidate. Compr. Psychiat. 13, 83 (1972).
Janowsky, D. S., El-Yousef, M. K., Davis, J. M., Hubbard, B.: Cholinergic adrenergic balance and affect. Presented at the 125th annual meeting of The American Psychiatric Assoc. (1972).
Janowsky, D. S., El-Yousef, M. K., Davis, J. M., Hubbard, B., Sekerke, H. J.: Cholinergic reversal of manic symptoms. Lancet 1972 I, 1236–1237.
Mazel, P., Bush, M. T.: Brain barbituate levels and anesthesia as influenced by physostigmine and epinephrine. Biochem. Pharmacol. 18, 579–586 (1969).
McKenzie, G. M.: Role of the tuberculum olfactorium in stereotyped behavior induced by apomorphine in the rat. Psychopharmacologia (Berl.) 23, 212–219 (1972).
Pfeiffer, C. C., Jenney, J. F. H.: The inhibition of the conditioned response and counteraction of schizophrenia by muscarinic stimulation of the brain. Ann. N.Y. Acad. Sci. 66, 753–764 (1957).
Randrup, A., Munkvad, I.: Behavioral stereotypics induced by pharmacologic agents. Pharmakopsychiat. 1, 18–26 (1967).
Scheel-Krüger, J.: Central effects of anticholinergic drugs measured by the apomorphine gnawing test in mice. Acta pharmacol. (Kbh.) 28, 1–16 (1970).
Scheel-Krüger, J.: Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of catecholamines in brain. Europ. J. Pharmacol. 14, 47–59 (1971).
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This research was supported in part by grant GM 15431, from the National Institutes of Health, grant MH 11468, from the National Institute of Mental Health, and by research support from The State of Tennessee Dept. of Mental Health.
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Janowksy, D.S., El-Yousef, M.K., Davis, J.M. et al. Cholinergic antagonism of methylphenidate-induced stereotyped behavior. Psychopharmacologia 27, 295–303 (1972). https://doi.org/10.1007/BF00429382
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DOI: https://doi.org/10.1007/BF00429382