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Constitutive mutation of cysJIH operon in a cysB deletion strain of Salmonella typhimurium

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Summary

In a cysB deletion strain a new mutation, denoted cys-2332 was isolated, which causes the constitutive expression of the cysJIH operon. cys-2332 is closely linked to cysJIH and presumably is located in the initiator region of this operon, rendering its expression independent of the cysB gene product and the internal inducer O-acetyl-L-serine. The presence of salfite reductase (encoded by cysI and cysJ) activity in a cysB - cys-2332 double mutant indicates that cysG, which is not linked to cysJIH but is required for the synthesis of the sulfite reductase co-factor siroheme, is not controlled by cysB.

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Communicated by G. O'Donovan

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Ostrowski, J., Hulanicka, D. Constitutive mutation of cysJIH operon in a cysB deletion strain of Salmonella typhimurium . Molec. Gen. Genet. 175, 145–149 (1979). https://doi.org/10.1007/BF00425530

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  • DOI: https://doi.org/10.1007/BF00425530

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