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Some neurochemical and neuropharmacological studies on the interactions between mescaline and 1-methyl-1,2,5,6-tetrahydropyridine-3-(N,N-diethylcarboxamide) (THPC)

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Abstract

The effect of THPC was studied on some pharmacological and neurochemical changes induced in the rat by mescaline. The results show that THPC antagonizes the effect of mescaline on the calorigenic action of a methyl-m-tyrosine in reserpinized mice. THPC potentiated the depletion of brain dopamine caused by H77/77 in combination with mescaline. In none of the other pharmacological or neurochemical tests was there any evidence that THPC antagonized or potentiated the effects of mescaline.

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Authors and Affiliations

  1. Pharmaceuticals Division, Pharmacology Section, Imperial Chemical Industries Limited, Alderley Park, Macclesfield, Cheshire

    B. E. Leonard

  2. The Medical School, University of Manchester, Manchester, UK

    P. D. Stonier

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  1. B. E. Leonard
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  2. P. D. Stonier
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Leonard, B.E., Stonier, P.D. Some neurochemical and neuropharmacological studies on the interactions between mescaline and 1-methyl-1,2,5,6-tetrahydropyridine-3-(N,N-diethylcarboxamide) (THPC). Psychopharmacologia 25, 1–13 (1972). https://doi.org/10.1007/BF00422611

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  • DOI: https://doi.org/10.1007/BF00422611

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