Summary
A correlation is demonstrated between chronic hemodialysis using cuprophane membranes (mean duration: 13 years) and pathological fractures (n = 7 in 6 patients) after lytic bone deposits of β2-microglobulin amyloid (n = 13 patients). The characteristic symptom complex includes painful impingement syndrome of the shoulder, carpal tunnel syndrome, painful hip and recurrent knee effusions. The first steps of the clinical diagnostic procedure are to demonstrate lytic defects in skeletal radiographs and to verify the presence of β2m by biopsy or puncture. Due to reduced regeneration capacity in amyloid bone lesions the resulting surgical therapy should aim at total joint replacement or augmented osteo synthesis. Definitive operative treatment should be aspired even in the absence of manifest fractures, as the natural course of the disease is characterized by progression of the bone destruction and a continuous pain syndrome.
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Scheumann, G.F.W., Holch, M., Nerlich, M.L. et al. Pathological fractures and lytic bone lesion of the femoral neck associated with β2-microglobulin amyloid deposition in long-term dialysis patients. Arch Orthop Trauma Surg 110, 93–97 (1991). https://doi.org/10.1007/BF00393881
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DOI: https://doi.org/10.1007/BF00393881