Skip to main content
Springer Nature Link
Log in

Evidence for an acid pH in rat renal inner medulla: paired measurements with liquid ion-exchange microelectrodes on collecting ducts and vasa recta

  • Short Communication
  • Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands
  • Published:
Pflügers Archiv Aims and scope Submit manuscript

Abstract

We reevaluated the pH in the renal medulla in rats. pH of the vasa recta blood was about 1 pH unit acidic in comparison to the pH of renal artery blood. During furosemideinduced diuresis pH of vasa recta blood increased whereas pH of collecting duct urine further decreased. The acidic pH in the rat renal inner medulla during antidiuresis raises important questions about the source of H+ in inner medulla.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Dantzler, WH, Silbernagl, S. (1991) Specificity of amino acid transport in renal papilla: microinfusion of Henle's loop and vasa recta. Am J Physiol 261: F495 - F504

    Google Scholar 

  2. Dubose TD, Caflisch CR, Bidani A (1984) Role of metabolic CO2 production in the generation of elevated renal cortical pCO2. Am J Physiol 246: F592 - F599

    Google Scholar 

  3. Dubose TD, Good DW (1992) Chronic hyperkalemia impairs ammonium transport and accumulation in the inner medulla of the rat. J Clin Invest 90: 1443 - 1449

    Google Scholar 

  4. Good DW, Caflisch CR, Dubose TD (1987) Transepithelial ammonia concentration gradients in inner medulla of the rat. Am J Physiol 252: F491 - F500

    Google Scholar 

  5. Graber ML, Bengele HH, Schwartz JH, Alexander EA (1981) pH and pCO2 profiles of the rat inner medullary collecting duct. Am J Physiol 241: F659-F668

    Google Scholar 

  6. Kaissling B (1982) Structural aspects of adaptive changes in renal electrolyte excretion. Am J Pysiol 243: F211-F226

    Google Scholar 

  7. Knepper M (1991) NH +4 transport in the kidney. Kidney Int 40: S95 - S102

    Google Scholar 

  8. Uhlich E, Baldamus CA, Ullrich KJ (1968) Verhalten von CO2-Druck und Bikarbonat im Gegenstromsystem des Nierenmarks. Pflügers Arch. 303: 31 - 48

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, University of Würzburg, Röntgenring 9, D-97070, Würzburg, Germany

    U. Kersting, H. Oberleithner & S. Silbernagl

  2. Department of Physiology, University of Arizona, 85724, Tucson, AZ, USA

    D. W. Dantzler

Authors
  1. U. Kersting
    View author publications

    You can also search for this author inPubMed Google Scholar

  2. D. W. Dantzler
    View author publications

    You can also search for this author inPubMed Google Scholar

  3. H. Oberleithner
    View author publications

    You can also search for this author inPubMed Google Scholar

  4. S. Silbernagl
    View author publications

    You can also search for this author inPubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kersting, U., Dantzler, D.W., Oberleithner, H. et al. Evidence for an acid pH in rat renal inner medulla: paired measurements with liquid ion-exchange microelectrodes on collecting ducts and vasa recta. Pflügers Arch. 426, 354–356 (1994). https://doi.org/10.1007/BF00374794

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00374794

Key words