Abstract
The effect of stannous chloride on tissue concentrations of zinc and copper was studied in female rats. The animals were subjected to repeated exposure to seven doses given every other day 2 mg Sn/kg, subcutaneously. About 60% of tin 113Sn was retained in the body. Of this amount, about 95% accumulated in the skin and hair. In the remaining organs the tin concentrations corresponded to 2.57 to 0.0001% of the retained dose. In comparison with the control group a 3-fold increase of the content of zinc was found in the liver while a decrease were revealed in the spleen, heart, brain, lungs, and especially in muscle. A statistically significant decrease of the copper content was found in the blood and brain.
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References
Benoy CJ, Hooper PA, Schneider R (1971) The toxicity of tin in canned fruit juices and solid foods. Food Cosmet Toxicol 9: 645
Dulka JJ, Risby TH (1976) Ultratrace metals in some environmental and biological systems. Anal Chem 8: 640A-653A
Durbin PW (1960) Metabolic characteristics within a chemical family. Health Phys 2: 225–258
Dziennik ustaw M.Z. i O.S. (1971)
Fritsch P, De Saint Blanquat G, Perache R (1977) Effect of various dietary components on absorption and tissue distribution of orally administered inorganic tin in rats. Food Cosmet Toxicol 15: 147
Hammond CR (1975) The Elements. In: Weast RC (ed) Handbook of chemistry and physics. 56th ed. CRS Press, Cleveland
Julshamn K, Utne F, Braekkan OR (1977) Interactions of cadmium with copper, zinc and iron in different organs and tissues of the rat. Acta Pharmacol Toxicol 41: 515–524
Luckey TD, Venugopal B, Hutcheson D (1975) Heavy metal toxicity, safety and hormology. G. Thieme Publishers Stuttgart
Nordberg FG (1978) Factors influencing metabolism and toxicity of metals: A consensus report by the task group on metal interaction. Environm Health Perspect 25: 3
Patel MC, Parab PB, Samuel AM, Ganatra RD (1979) Labeling of blood cells with T0-99m after oral administration of SnCl2: Concise Communication. J Nucl Med 20: 877–881
Piotrowski JK, Coleman DO (1980) Environmental hazards of heavy metals: Summary evaluation of lead, cadmium and mercury. In: UNEP, Nairobi and MARC, A General Report, University of London
Piotrowski JK, Szymańska JA, Mogilnicka EM, Zelazowski AJ (1979) Renal metal binding proteins. Experientia [Suppl] 34: 363–371
Schroeder HB, Balassa JJ, Tipton JH (1964) Abnormal trace metals in man. Tin J Chron Dis 17: 483
Stonard MD, Webb M (1976) Influence of dietary cadmium on the distribution of the essential metals copper, zinc and iron in tissues of the rat. Chem Biol Interact 15: 349
Szymańska JA, Zychowicz M, Zelazowski AJ, Piotrowski JK (1978) Effect of selenium on the organ distribution and binding of bismuth in rats tissues. Arch Toxicol 40: 131–141
Szymańska JA, Zelazowski AJ (1979) Effect of cadmium, mercury and bismuth on the copper content in rat tissues. Environ Res 19: 121–126
Szymanska JA, Zelazowski AJ, Kawiorski S (1981) Some aspects of bismuth metabolism. Clin Toxicol (in press)
Widdowson EM, Dickerson JWT (1964) In: Comar CL, Bronner F (eds) Mineral metabolism. Academic Press, New York
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Chmielnicka, J., Szymańska, J.A. & Snieć, J. Distribution of tin in the rat and disturbances in the metabolism of zinc and copper due to repeated exposure to SnCl2 . Arch Toxicol 47, 263–268 (1981). https://doi.org/10.1007/BF00332392
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DOI: https://doi.org/10.1007/BF00332392