Summary
Polyovular follicles (PF) occur in the ovary of 30-day-old offspring of ICR/JCL mice given 4 daily subcutaneous injections of 20–2,000 μg diethylstilbestrol (DES)/day from days 15 to 18 of gestation. PF containing 2–9 oocytes per follicle in the prenatally DES-exposed mice are increased 33- to 112-fold as compared to controls. In 5- to 25-day-old offspring of mothers given injections of 2,000 μg DES/day, PF are observed 17–65 times more frequent than in controls.
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References
Boylan ES (1978) Morphological and functional consequences of prenatal exposure to diethylstilbestrol in the rat. Biol Reprod 19:845–863
Fekete E (1950) Polyovular follicles in the C58 strain of mice. Anat Rec 108:699–707
Forsberg J-G, Tenenbaum A, Rydberg C, Sernvi C (1985) Ovarian structure and function in neonatally estrogen treated female mice. In: International Symposium on Estrogens in the Environment (in press)
Hartman CG (1926) Polynuclear ova and polyovular follicles in the opossum and other mammals, with special reference to the problem of fecundity. Am J Anat 37:1–51
Herbst AL, Bern HA (1981) Developmental effects of diethylstilbestrol (DES) in pregnancy. Thieme-Stratton, New York
Iguchi T, Ohta Y, Takasugi N (1976) Mitotic activity of vaginal epithelial cells following neonatal injections of different doses of estrogen in mice. Dev Growth Differ 18:69–78
Iguchi T, Takasugi N, Bern HA, Mills KT (1986) Frequent occurrence of polyovular follicles in ovaries of mice exposed neonatally to diethylstilbestrol. Teratology (in press)
Kent HA Jr (1960) Polyovular follicles and multinucleate ova in the ovaries of young mice. Anat Rec 137:521–524
McLachlan JA, Newbold RR, Bullock BC (1980) Long-term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol. Cancer Res 40:3988–3999
Newbold RR, Bullock BC, McLachlan JA (1984) Exposure to diethylstilbestrol during pregnancy permanently alters the ovary and oviduct. Biol Reprod 28:735–744
Takasugi N (1976) Cytological basis for permanent vaginal changes in mice treated neonatally with steroid hormones. Int Rev Cytol 44:193–224
Tenenbaum A, Forsberg J-G (1985) Structural and functional changes in ovaries from adult mice treated with diethylstilbestrol in the neonatal period. J Reprod Fert 73:465–477
Wordinger RJ, Highman B (1984) Histology and ultrastructure of the adult mouse ovary following a single prenatal exposure to diethylstilbestrol. Virchows Arch B 45:241–253
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Iguchi, T., Takasugi, N. Polyovular follicles in the ovary of immature mice exposed prenatally to diethylstilbestrol. Anat Embryol 175, 53–55 (1986). https://doi.org/10.1007/BF00315455
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DOI: https://doi.org/10.1007/BF00315455