Summary
A patient is described, who had muscle necrosis occurring with hypokalemia and a factitious mineralocorticoid excess syndrome. The syndrome was due to the prolonged use of a nasal spray containing 9-alpha-fluoroprednisolone acetate, a steroid with potent mineralocorticoid activity. It is emphasized that intranasal administration of steroid compounds must be considered in the differential diagnosis of hypokalemia and related muscle disorders.
Zusammenfassung
Es wird ein Patient beschrieben, der hypokaliaemische Muskelnekrosen, ausgelöst durch einen exogenen Überschuß von Mineralcorticoiden, aufweist. Die Ursache war der langdauernde Gebrauch eines 9-alpha-fluorprednisolon-Nasensprays, ein Steroid mit einer starken mineralcorticoiden Aktivität. Intranasal verabreichte Steroide müssen in der Differentialdiagnose von Hypokaliaemie und dadurch hervorgerufenen Muskelveränderungen in Betracht gezogen werden.
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Cantello, R., Bergamini, L., Delsedime, M. et al. Hypokalemic myopathy associated with intranasal steroid use (factitious mineralocorticoid excess syndrome). J Neurol 226, 265–268 (1982). https://doi.org/10.1007/BF00313399
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DOI: https://doi.org/10.1007/BF00313399