Abstract
The effect of cyanide on the distribution of cobalt was studied by injecting mice i.p. with potassium cyanide 61.4 μmoles/kg, followed 1 min later by 60CoCl2 38.5 μmoles/kg i.v. Blood and tissue concentrations of 60Co were then determined up to 48 h after injection and the results were compared with those obtained from control animals receiving 60CoCl2 only. In animals treated with cobalt plus cyanide, considerably higher concentrations of 60Co were found in the spleen in comparison with controls during the whole observation period, whereas the 60Co concentration in the pancreas was lower than that of controls during the first 4 h. In other tissues no significant differences between cyanide-treated animals and controls were noticed. Determination of complex-bound cyanide demonstrated that the increased uptake of cobalt in the spleen observed in cyanide-treated animals was due to cobalt-cyanide complex(es). Cyanide did not affect the plasma protein binding of cobalt.
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Frankenberg, L. Effect of cyanide on the distribution of 60Co in mice. Arch Toxicol 51, 131–137 (1982). https://doi.org/10.1007/BF00302753
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DOI: https://doi.org/10.1007/BF00302753