Summary
A 0.9 kb cDNA fragment, corresponding to a large part of Rhesus monkey pepsinogen A mRNA, was used as probe for the chromosomal localization of the human pepsinogen A gene(s) using human-rodent somatic cell hybrids. Southern blot analysis of 14 human-Chinese hamster and three human-mouse cell hybrids, strongly indicates that the human PGA locus is on chromosome 11. The human-mouse hybrids, containing a translocation involving chromosome 11, allow sublocalization to the region q12-pter.
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Zelle, B., Geurts van Kessel, A., de Wit, J. et al. Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11. Hum Genet 70, 337–340 (1985). https://doi.org/10.1007/BF00295373
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DOI: https://doi.org/10.1007/BF00295373