Summary
1,2-Diformylhydrazine was administered in drinking water as a 2% solution to randomly bred Swiss albino mice for life from 6 weeks of age. As a result of treatment, the lung tumor incidence rose from 15 to 96% in females and from 22 to 82% in males. The treatment had no statistically significant effect on the development of other types of tumors. Histopathologically, the neoplasms exhibited the characteristic appearance of adenomas and adenocarcinomas of the lungs.
The work is part of a series of studies aimed at revealing the relative carcinogenic potency of mono and dialkyl-hydrazines and also their possible environmental significance as cancer causative agents.
Zusammenfassung
1,2-Diformylhydrazin wurde in einer 2%igen Lösung 6 Wochen alten Swiss-Mäusen auf Dauer im Trinkwasser verabreicht. Die Lungentumor-Häufigkeit stieg von 15% (in Kontrollen) auf 96% in weiblichen und von 22% auf 82% in männlichen Tieren. Histopathologisch besaßen diese Neoplasmen die charakteristische Erscheinungsform von Adenom und Adenokarzinom der Lunge. Die Behandlung zeigte keine erkennbare Wirkung hinsichtlich der Entwicklung anderer Tumoren.
Diese Arbeit ist Teil einer Untersuchungsreihe, welche die relative karzinogene Wirkung von Mono und Dialkylhydrazinen und deren eventuelle Bedeutung als krebserzeugende Substanzen der Umwelt zeigen soll.
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Supported by USPHS Contract N01 CP33278 from the National Cancer Institute, NIH, USA
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Toth, B., Erickson, J. Lung tumorigenesis by 1,2-diformylhydrazine in mice. Z. Krebsforsch. 92, 11–16 (1978). https://doi.org/10.1007/BF00284090
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DOI: https://doi.org/10.1007/BF00284090