Summary
Chronic renal failure was induced in mice using bilateral electrocoagulation of the renal cortex. Thermal injury via an angled point cautery was applied to the fully exteriorized right kidney. Following a 10-day interval the left kidney was injured in a similar fashion. The incidence of local complications was negligible and because of the limited blood loss, very small laboratory animals can be used. By restricting trauma to varying proportions of the visible cortex graded levels of injury were obtained. Thus this model can produce a uniform pattern of renal failure and will therefore facilitate the acquisition of information on the biological consequences of chronic uraemia.
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References
Boudet NK, Mann PP, Sausse A, Funck-Brentano JL (1978) Experimental chronic renal failure in the rat by electrocoagulation of the renal cortex. Kidney Int 14:82–86
Bricker NS, Klahr S, Rieselbach RE (1964) The functional adaptation of the diseased kidney. I. Glomerular filtration rate. J Clin Invest 43:1915–1921
Grouls V, Helpap B (1978) DNA-synthesis in the rat thymus after focal thermolesions on abdominal organs. Res Exp Med (Berl) 173:229–237
Helpap B, Kaiser R (1981) The cellular response of T and B dependent areas of the spleen after focal thermocoagulation of liver and kidney. Virchows Arch 36:291–302
Shankel SW, Robson AM, Bricker NS (1967) On the mechanism of the splay in the glucose titration curve in advanced experimental renal disease in the rat. J Clin Invest 46:164–173
Souhami RL (1973) Antibody production and catabolism in uremia. Br J Exp Pathol 54:380–387
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Gagnon, R.F., Duguid, W.P. A reproducible model for chronic renal failure in the mouse. Urol. Res. 11, 11–14 (1983). https://doi.org/10.1007/BF00272702
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DOI: https://doi.org/10.1007/BF00272702