Abstract
A 29 year-old-man presenting with advanced metastatic malignant melanoma was successfully imaged using carbon-11 (11C) labeled alpha-aminoisobutyric acid (AIB), a synthetic, non-metabolized amino acid transported into viable cells by the A-type, or alanine-preferring, amino acid transport system. Tumor located in the hilum of the lung was well visualized with 11C-AIB prior to chemotherapy. A gallium image with liver subtraction using 99mTc-sulfur colloid demonstrated regions of increased activity in liver which correlated with regions of increased activity on the 11C-AIB liver image.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bigler RE, Zanzonico PB, Sgouros, G (1983) Compartmental model for in vivo assessment of A-type amino acid transport. J Nucl Med 24:P90 (Abstr)
Bigler RE, Zanzonico PB, Schmall B, Conti PS, Dahl JR, Rothman L, Sgouros G, MacEwen EG (1985) Evaluation of [1-C-11]-α-aminoisobutyric acid for tumor detection and amino acid transport measurement: Spontaneous canine tumor studies. Eur J Nucl Med 10:48–55
Blasberg R, Patlack C, Shapiro W, Fenstermacher J (1979) Metastatic brain tumors: Local blood flow and capillary permeability. Neurology 29:547 (Abstr)
Bockslaff H, Kloster G, Dausch D, Schad K, Hundeshagen H, Stöcklin G (1981) First clinical results using L-3-123I-α-methyltyrosine for the non-invasive detection of intraocular melanomas. In: Schmidt HAE, Wolf F (eds) Nuklearmedizin. Schattauer, Stuttgart New York, pp 840–844
Bockslaff H, Spitznas M, Hahn I, Kloster G (1981) Noncontact detection of experimental amelanotic ocular melanoma with L-3-123-iodo-α-methyltyrosine. Ophthalmologie 217:255–266
Conti PS, Schmall B (1985) Synthesis of carbon-11 labeled alpha-methyl amino acids, potential in vivo substrate-specific tracers of enzymatic processes. 190th National Meeting of the American Chemical Society, Chicago, Illinois, September 9–13
Conti PS, Sordillo EM, Sordillo PP, Schmall B (1983) Human melanoma heterotransplants in nude mice: Tumor-localization of radiolabeled alpha-aminoisobutyric acid (AIB), a potential agent for imaging with positron emission tomography. J Nucl Med 24:P110 (Abstr)
Conti PS, Sordillo EM, Sordillo PP, Schmall B (1985) Tumorlocalization of alpha-aminoisobutyric acid (AIB) in human melanoma heterotransplants. Eur J Nucl Med 10:45–47
Dunzendorfer U, Schmall B, Bigler RE, Zanzonico PB, Conti PS, Dahl JR, Kleinert EL, Whitmore WF Jr (1981) Synthesis and body distribution of alpha-aminoisobutyric acid 1-C-11 in normal and prostate cancer-bearing rats after chemotherapy. Eur J Nucl Med 6:535–538
Foster DO, Pardee AB (1969) Transport of amino acids by confluent and nonconfluent 3T3 and polyoma virus-transformed 3T3 cells growing on glass cover slips. J Biol Chem 244:2675–2681
Gelbard AS, Benua RS, Reiman RE, McDonald JM, Vomero JJ, Laughlin JS (1980) Imaging of the human heart after administration of L-(N-13) glutamate. J Nucl Med 21:988–991
Isselbacher KJ (1972) Sugar and amino acid transport by cells in culture-differences between normal and malignant cells. N Engl J Med 286:929–933
Johnstone RM, Scholefield PG (1965) Amino acid transport in tumor cells. Adv Cancer Res 9:143–226
Kloster G, Bockslaff H (1982) L-3-123I-alpha-methyl-tyrosine for melanoma detection: A comparative evaluation. Int J Nucl Med 9:259–269
Milder GB (1951) Some aspects of nitrogen and energy metabolism in cancerous subjects: A review. Cancer Res 11:821–829
Olendorf WH (1971) Brain uptake of radiolabeled amino acids amines and hexoses after arterial injection. Am J Physiol 221:1629–1639
Packer S (1984) Tumor detection with radiopharmaceuticals. Semin Nucl Med 14:21–30
Parnes JR, Isselbacher KJ (1978) Transport alerations in virus-transformed cells. Prog Exp Tumor Res 22:79–122
Rapoport SI (1976) Blood-brain barrier in physiology and medicine. Raven Press Books, New York, pp 177–206
Reiman RE, Rosen G, Gelbard AS, Benua RS, Laughlin JS (1982) Imaging of primary Ewing sarcoma with N-13 L-glutamate. Radiology 142:495–500
Schain RJ, Watanabe KS (1972) Distinct patterns of entry of two non-metabolizable amino acids into brain and other organs of infant guinea pigs. Neurochemistry 19:2279–2288
Schmall B, Bigler RE, Zanzonico PB, Conti PS, Dahl JR, Lee R (1982) Tumor visualization and pharmacokinetic studies with C-11 alpha-aminoisobutyric acid (AIB) in dogs bearing spontaneous cancers. In: Raynaud C (ed) Nuclear Medicine and Biology. Oxford, Pergamon Press, pp 3204–3207
Schmall B, Conti PS, Bigler RE, Zanzonico PB, Dahl JR, Sundoro-Wu BM, Jacobsen JK, Lee R (1984) Synthesis and quality assurance of C-11 alpha-aminoisobutyric acid (AIB), a potential radiotracer for imaging and amino acid transport studies in normal and malignant tissues. Int J Nucl Med Biol 3/4:209–214
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Conti, P.S., Sordillo, P.P., Schmall, B. et al. Tumor imaging with carbon-11 labeled alpha-aminoisobutyric acid (AIB) in a patient with advanced malignant melanoma. Eur J Nucl Med 12, 353–356 (1986). https://doi.org/10.1007/BF00263819
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00263819