Summary
In 36 patients with renal carcinomal ploidy and cell cycle analysis of the tumour tissues by flow cytophotometry were performed. Considering the tumour stages pT, pN, and M no relationship between stage and DNA distribution could be established. With reference to the histological grading, grade I tumours showed only euploid DNA distributions, whereas grade II and III carcinomas exhibited both euploid and aneuploid DNA patterns. Whether ploidy analysis is correlated with the prognosis of the tumour disease remains to be determined.
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References
Arner O, Blanck C, Schreeb Tv (1965) Renal adenocarcinoma. Acta Chir Scand 346:11
Baisch H, Otto U, König K, Köllermann M, Linden WA (1982) DNA content of human kidney carcinoma cells in relation to histological grading. Br J Cancer 45:878
Barlogie B, Göhde W, Johnston DA, Smallwood L, Schumann J, Drewinko B, Freireich EJ (1978) Determination of ploidy and proliferative characteristics of human solid tumors by pulse cytophotometry. Cancer Res 38:3333
Bennington JL, Beckwith JB (1975) Tumors of the kidney, renal pelvis and ureter. Armed Forces Inst of Pathology, Washington, USA
Böhm N, Sandritter W (1975) DNA in human tumors: A cytophotometry study. Curr Top Pathol 60:151
Boxer RJ, Waisman J, Lieber MM, Mampaso FM, Skinner DG (1979) Renal carcinoma: Computer analysis of 96 patients treated by nephrectomy. J Urol 122:598
Claes G (1963) Concerning the relationship between the morphology and the symptomatology of hypernephroma. Urol Int 15:265
Gustafson H, Tribukait B, Esposti PL (1982) DNA profile and tumour progression in patients with superfical bladder tumours. Urol Res 10:13
Hermanek P, Sigel A, Chlepas S (1976) Histological grading of renal cell carcinoma. Eur Urol 2:189
Hofstädter F, Ehlich P (1978) DNS-Feulgenzytophotometrie bei Nieren-Parenchymkarzinomen verschiedenen Malignitätsgrades. Verh Dtsch Ges Pathol 62:375
Jakobsen A, Bichel P, Sell A (1979) Flow cytometric investigations of human bladder carcinoma compared to histological classification. Urol Res 7:109
Krug H (1976) Impulszytophotometrische Untersuchungen an Tumormaterial. Arch Geschwulstforsch 46:110
McNichols DW, Segura JW, DeWeerd JH (1981) Renal cell carcinoma: long-term survival and late recurrence. J Urol 126:17
Myers GH, Fehrenbaker LG, Kelalis PP (1968) Prognostic significance of renal vein invasion by hypernephroma. J Urol 100:420
Mostofi FK, Sesterhenn IA, Sobin LH (1981) Histological typing of kidney tumours. Int Histol Class of Tumours WHO, Genf
Schwabe HW, Adolphs H-D (1982) Improved application of impulse cytophotometry for the diagnosis of urinary bladder carcinoma. Urol Res 10:61
Skinner DG, Colvin RB, Vermillion CD, Pfister RC, Leadbetter WF (1971) Diagnosis and management of renal cell carcinoma. Cancer 28:1165
Stambolis C, Doppl W, Pust R, Kracht J (1981) Das Nierenzellkarzinom. Med Welt 32:1283
Stöhr M, Gebhard U, Goerttler K (1976) Computer assistance in multiparameter flow microphotometry of mammalian cells. Biotechnol Bioeng 18:1057
Syrjänen K, Hjelt L (1978) Grading of human renal adenocarcinoma. Scand J Urol Nephrol 12:49
Thackray AC (1964) The pathology and spread of renal adenocarcinoma: in riches neuplastic disease at various sites. Livingstone, Edinburgh V, UK
Tribukait B, Esposti P (1978) Quantitative flow-micro-fluorometric analysis of DNA in cells from neoplasms of the urine bladder: Correlation of aneuploidy with histological grading and cytological findings. Urol Res 6:201
Tribukait B, Gustafson H (1980) Impulscytophotometrische DNS Untersuchungen bei Blasenkarzinomen. Onkologie 6:278
UICC Union International Contre le Cancer (1979) TNM-Klassifikation der malignen Tumoren. Springer, Berlin Heidelberg New York
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Schwabe, H.W., Adophs, H.D. & Vogel, J. Flow-cytophotometric studies in renal carcinoma. Urol. Res. 11, 121–125 (1983). https://doi.org/10.1007/BF00257716
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DOI: https://doi.org/10.1007/BF00257716