Skip to main content

Advertisement

SpringerLink
Log in

Two antiemetic regimens do not impair chemical xenogenization induced in vivo by 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide

  • Original Articles
  • Xenogenization, Dexamethasone, Diazepam, Orphenadrine Hydrochloride, Tumor Cell Immunogenicity
  • Published:
Cancer Chemotherapy and Pharmacology Aims and scope Submit manuscript

Summary

The possible interference with 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC)-mediated chemical xenogenization (CX) by antiemetic drugs was studied. DTIC was given alone or in combination with either dexamethasone or metoclopramide plus orphenadrine hydrochloride plus diazepam to CD2F1 mice bearing the histocompatible L1210 leukemia. Tumor cells were collected from treated animals and inoculated into histocompatible untreated and drug-treated recipients, for eight transplant generations. More than 50% of intact hosts rejected tumor cells between the fourth and sixth transplant generation, independently of antiemetic treatments. Positive controls treated with DTIC plus quinacrine (QC) confirmed that this antimutagenic compound entirely abrogates CX. The present results point out that the antiemetic regimens investigated in this study do not prevent CX. Since DTIC treatment requires intensive antiemetic support in man, these data are of clinical relevance for CX-oriented immunochemotherapy protocols.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ballerini P, D'Atri S, Franchi A, Lassiani L, Ragona G, Faggioni A, Bonmassar E, Giuliani A (1988) Pharmacological manipulation of membrane antigens of cancer cells. In: Advances in immunomodulation. Pythagora Press, Rome-Milan, p 251

    Google Scholar 

  2. Bonmassar A, Frati L, Fioretti MC, Romani L, Giampietri A, Goldin A (1979) Changes of immunogenic properties of K-36 lymphoma treated in vivo with 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC). Eur J Cancer 15: 933

    Google Scholar 

  3. Bonmassar E, Bonmassar A, Vladamudi S, Goldin A (1970) Immunological alteration of leukemic cells in vivo after treatment with antitumor drugs. Proc Natl Acad Sci USA 66: 1089

    Google Scholar 

  4. Bonmassar E, Bonmassar A, Vadlamudi S, Goldin A (1972) Antigenic changes of L1210 leukemia in mice treated with 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide. Cancer Res 32: 1446

    Google Scholar 

  5. Bonmassar E, Testorelli C, Franco P, Goldin A, Cudkowicz G (1975) Changes of the immunogenic properties of a radiation-induced mouse lymphoma following treatment with antitumor drugs. Cancer Res 35: 1957

    Google Scholar 

  6. Boon T (1983) Antigenic tumor cell variants obtained with mutagens. Adv Cancer Res 39: 121

    Google Scholar 

  7. Contessa AR, Giampietri A, Bonmassar A, Goldin A (1979) Increased immunogenicity of L1210 leukemia following short-term exposure to 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) in vivo or in vitro. Cancer Immunol Immunother 7: 71

    Google Scholar 

  8. Contessa AR, Bonmassar A, Giampietri A, Circolo A, Goldin A, Fioretti MC (1981) In vitro generation of a highly immunogenic subline of L1210 leukemia following exposure to 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide. Cancer Res 41: 2476

    Google Scholar 

  9. Fioretti MC (1975) Immunopharmacology of 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC). Pharmacol Res Commun 7: 481

    Google Scholar 

  10. Fioretti MC, Romani L, Bonmassar A, Taramelli D (1980) Appearance of strong transplantation antigens in nonimmunogenic lymphoma following drug treatment in vivo. J Immunopharmacol 2: 189

    Google Scholar 

  11. Fioretti MC, Bianchi R, Romani L, Bonmassar E (1983) Drug-induced immunogenic changes of murine leukemia cells: dissociation of onset of resistance and emergence of novel immunogenicity. J Natl Cancer Inst 71: 1247

    Google Scholar 

  12. Fioretti MC, Romani L, Bonmassar E (1983) Antigenic changes related to drug-action. In: Biology of Cancer. Alan R Liss, New York, p 435

    Google Scholar 

  13. Giampietri A, Bonmassar E, Goldin A (1978) Drug-induced modulation of immune response in mice: effects of 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) and cyclophosphamide (Cy). J Immunopharmacol 1: 61

    Google Scholar 

  14. Giampietri A, Fioretti MC, Goldin A, Bonmassar E (1980) Drug-mediated antigenic changes in murine leukemia cells. Antagonistic effects of Quinacrine, an antimutagenic compound. J Natl Cancer Inst 64: 297

    Google Scholar 

  15. Giampietri A, Bonmassar A, Puccetti P, Circolo A, Goldin A, Bonmassar E (1981) Drug-mediated increase of tumor immunogenicity in vivo for a new approach to experimental cancer immunotherapy. Cancer Res 41: 681

    Google Scholar 

  16. Houchens DP, Bonmassar E, Gaston MR, Kende M, Goldin A (1976) Drug-mediated immunogenic changes of virus-induced leukemia in vivo. Cancer Res 36: 1347

    Google Scholar 

  17. Kris MG, Gralla RJ, Tyson LB, Clark RA, Kelsen DP, Reilly LK, Groshen S, Boel G, Kalman LA (1985) Improved control of cisplatin-induced emesis with high-dose metoclopramide and with combination of metoclopramide, dexamethasone and diphenhydramine. Cancer 55: 527

    Google Scholar 

  18. Nicolin A, Spreafico F, Bonmassar E, Goldin A (1986) Antigenic changes of L5178Y lymphoma after treatment with 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide in vivo. J Natl Cancer Inst 56: 89

    Google Scholar 

  19. Puccetti P, Giampietri A, Fioretti MC (1978) Long-term depression of two primary immune responses induced by a single dose of 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC). Experientia 34: 799

    Google Scholar 

  20. Riccardi C, Fioretti MC, Giampietri, A, Puccetti A, Goldin A (1978) Growth and rejection patterns of murine lymphoma cells antigenically altered following drug treatment in vivo. Transplantation 25: 63

    Google Scholar 

  21. Romani L, Fioretti MC, Bonmassar E (1979) In vitro generation of primary cytotoxic lymphocytes against L5178Y leukemia antigenically altered by 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide in vivo. Transplantation 28: 218

    Google Scholar 

  22. Romani L, Puccetti P, Fioretti MC, Mage MG (1985) Humoral response against murine lymphoma cells xenogenized by drug treatment in vivo. Int J Cancer 36: 225

    Google Scholar 

  23. Santoni A, Kinney Y, Goldin A (1978) Secondary cytotoxic response in vitro against Moloney lymphoma cells antigenically altered by drug-treatment in vivo. J Natl Cancer Inst 60: 109

    Google Scholar 

  24. Segal DM, Sharrow SO, Jones JF, Siraganian RP (1981) Fc (IgG) receptors on rat basophilic leukemia cells. J Immunol 126: 138

    Google Scholar 

  25. Silvestrini R, Testorelli C, Goldin A, Nicolin A (1977) Cell kinetics and immunogenicity of lymphoma cells treated with 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide. J Natl Cancer Inst 19: 664

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Experimental Medicine and Biochemical Sciences, Second University of Rome, Rome, Italy

    Paola Ballerini, Daniela Piccioni & Enzo Bonmassar

  2. Institute of Experimental Medicine, National Council of Research (CNR), Rome

    Annibale Franchi

  3. Institute of Pharmacology, University of Perugia, Perugia, Italy

    Patrizia Fuschiotti

Authors
  1. Paola Ballerini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Annibale Franchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Patrizia Fuschiotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Daniela Piccioni
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Enzo Bonmassar
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ballerini, P., Franchi, A., Fuschiotti, P. et al. Two antiemetic regimens do not impair chemical xenogenization induced in vivo by 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide. Cancer Chemother. Pharmacol. 24, 359–362 (1989). https://doi.org/10.1007/BF00257442

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00257442

Keywords

Search

Navigation