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Myocardial uptake of meta-[123I]-iodobenzylguanidine ([123I]-MIBG) in patients with myocardial infarct

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Abstract

Meta-123I-iodobenzylguanidine (123I-MIBG), which is an analog of norepinephine, can be used to evaluate the integrity and function of sympathetic nerve endings in the heart. Myocardial uptake of 123I-MIBG was studied in 30 myocardial infarction patients and compared with the distribution of blood flow assessed with 201Tl. It was found that when a cold defect appeared on the 201Tl scintigram, its localization was identical to the cold defect on the 123I-MIBG scintigram. On the other hand, in three cases, a defect was found on the 123I-MIBG scintigram, corresponding to the electrocardiographic localization of the infarct, whereas the 201Tl scintigram was normal. Most strikingly, the present study shows that drugs (antagonists of the adrenergic receptors, calcium antagonists, amiodarone) decrease or even abolish (as in the case of labetalol) myocardial uptake of 123I-MIBG. Consequently, any interpretation of the 123I-MIBG scintigram must take into account the treatment administered.

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Authors and Affiliations

  1. Faculté de Médecine Grenoble, Laboratoire d'Etudes des Radiopharmaceutiques URA CNRS 214, F-38700 La, Tronche, France

    Daniel Fagret & Michel Comet

  2. Clinique Cardiologique, Centre Hospitalier Régional et Universitaire, Grenoble, France

    Jean-Eric Wolf

Authors
  1. Daniel Fagret
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  2. Jean-Eric Wolf
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  3. Michel Comet
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Fagret, D., Wolf, JE. & Comet, M. Myocardial uptake of meta-[123I]-iodobenzylguanidine ([123I]-MIBG) in patients with myocardial infarct. Eur J Nucl Med 15, 624–628 (1989). https://doi.org/10.1007/BF00256942

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  • DOI: https://doi.org/10.1007/BF00256942

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