Abstract
For measurement of glomerular filtration rate the usefulness of diethyl triamino penta acic (DTPA) labelled with 113mIndium has been explored.
The labelling procedure is very simple, since eluate from an 113mIn generator can be used directly for labelling DTPA.
The in vitro and in vivo binding of 113mIn to DTPA in competition with serum proteins was studied by gel-filtration. The radioactivity within the 113mIn-DTPA peak represented 100.6, 107.1 and 99.6% of the amount of radioactivity applied to the gel column for the in vivo studies, and 102.0 and 101.4% for the in vitro studies.
Furthermore, the clearance of 113mIn-DTPA was compared to the clearance of 125I-iothalamate using the constant infusion technique. The clearance values were found to be nearly equal (r=0.996).
It is concluded that 113mIn is almost entirely bound to DTPA after intravenous injection of the 113mIn-DTPA complex, and that the complex is a suitable agent for determination of glomerular filtration rate.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Atkins, H.L., Klopper, J.F., Fekelman, W.C.: The technetium-99m DTPA renal study. In: Medical Radioisotope Scintigraphy 1972, vol 2, pp. 251–261. Vienna: IAEA 1973
Best, C.N., Peachey, I.A.: 113mIn-DTPA as a simple test of renal function. J. Nucl. Med. 11, 621–622 (1970)
Elwood, C.M., Sigman, E.M., Treger, C.: The measurement of glomerular filtration rate with 125I-sodium iothalamate (Conray). Br. J. Radiol. 40, 581–583 (1967)
Klopper, J.F., Hanser, W., Atkins, H.L., Eckelman, W.C., Richards, P.: Evaluation of 99mTC-DTPA for the measurement of glomerular filtration rate. J. Nucl. Med. 13, 107–110 (1971)
Norman, N.: Effective renal plasma flow of the individual kidney. Determination on the basis of the [131I] hippuran renogram. Scand. J. clin. Lab. Invest. 30, 395–403 (1972)
Piepsz, A., Erbsmann, F., Vainsel, M., Cantraine, F.: Determination of glomerular filtration rate in children by external measuerment of the disappearance of 113m-Indium-DTPA in plasma. Biomedicine 20, 192–197 (1974)
Pors Nielsen, S., Lehd Møller, M., Trap-Jensen, J.: 99mTc-DTPA scintillation—camera renography: A new method for estimation of single kidney function. J. Nucl. Med. 18, 112–117 (1977)
Welch, M.J., Welch, T.J.: Solution chemistry of carrier-free Indium. pp. 74–77. In: Subramanian, G., Rhodes, B.A., Cooper, J.S. and Sodd, V.J. (Eds.). Radiopharmaceuticals: New York: Society of Nuclear Medicine Inc. 1975
Wochner, R.D., Adatepe, M., Amberg, A.V., Potchen, E.J.: A new method for estimation of plasma volume with the use of the distribution space of indium-113m-transferrin. J. Lab. clin. Med. 75, 711–720 (1970)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Johansson, R.S., Falch, D.K. 113mIn-DTPA, a useful compound for the determination of glomerular filtration rate (GFR). Eur J Nucl Med 3, 179–181 (1978). https://doi.org/10.1007/BF00256640
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00256640