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Prevention of adriamycin toxicity

  • Original Articles
  • Adriamycin Toxicity
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Summary

Mice treated with lethal doses of adriamycin (A1) (IP) are rescued with a single IP dose of 3,5,5-trimethyl-2-morpholinon-3-yl radical dimer (TM3). The in vivo rescue is assumed to be analogous to the in vitro reaction of TM3 with A1 that produces the non-toxic 7-deoxy-adriamycinone (7dAone). TM3 prevents death if given within 60 min following A1 administration. Control A1-treated mice died by 8 days (median survival time) whereas TM3 rescued A1-treated mice had a median survival time of greater than 60 days.

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Author information

Author notes

  1. Allen R. Banks & Ted Jones

    Present address: Applied Molecular Genetics, Inc., 91320, Thousand Oaks, CA, USA

Authors and Affiliations

  1. AMC Cancer Research Center and Hospital, 80214, Lakewood, Colorado

    Allen R. Banks & Ted Jones

  2. Department of Chemistry, University of Colorado, 80309, Boulder, Colorado

    Tad H. Koch

  3. Laboratory of Medicinal Chemistry and Pharmacology, DCT, NCI, 20205, Bethesda, Maryland, USA

    Rosalind D. Fiedman & Nicholas R. Bachur

Authors
  1. Allen R. Banks
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  2. Ted Jones
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  3. Tad H. Koch
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  4. Rosalind D. Fiedman
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  5. Nicholas R. Bachur
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Additional information

We dedicate this paper to the memory of Dr. Solomon Garb of the AMC Cancer Research Center and Hospital

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Banks, A.R., Jones, T., Koch, T.H. et al. Prevention of adriamycin toxicity. Cancer Chemother. Pharmacol. 11, 91–93 (1983). https://doi.org/10.1007/BF00254252

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  • DOI: https://doi.org/10.1007/BF00254252

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