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Analysis of unitary EPSPs mediated by the newly-formed cortico-rubral synapses after lesion of the nucleus interpositus of the cerebellum

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Summary

  1. 1.

    Unitary EPSPs were recorded intracellularly from neurons of the red nucleus (RN) by stimulating the cortico-rubral fibers in normal cats as well as those with chronic lesion of interpositus nucleus (IP) of the cerebellum.

  2. 2.

    Two groups of unitary EPSPs were recorded in cats with IP lesion. One consisted of cortico-rubral unitary EPSPs with a shorter time to peak and larger amplitude than those in normal cats. The other consisted of unitary EPSPs of the normal range.

  3. 3.

    The appearance of the fast rising group of cortico-rubral EPSPs caused by IP lesions was theoretically predictable based on Rall's compartmental model by assuming that new synapses were formed close to the soma of the RN cells.

  4. 4.

    The amplitude of the fast rising EPSPs increased more prominently by hyperpolarizing the membrane potential than that of the slowly rising ones.

  5. 5.

    It was concluded that the fast rising group of unitary EPSPs which appeared following IP lesion was due to the formation of new synapses on the proximal portion of the soma-dendritic membrane of RN cell.

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References

  • Clemente, C.D.: Regeneration in the central nervous system. Int. Rev. Neurobiol. 6, 257–301 (1964)

    Google Scholar 

  • King, J.S., Martin, G.F., Conner, J.B.: A light and electron microscopic study of cortico-rubral projections in the oppossum, Didelphis marsupialis virginiana. Brain Res. 38, 251–265 (1972)

    Google Scholar 

  • Lynch, G., Deadwyler, S., Cotman, C.: Postlesion axonal growth produces permanent functional connections. Science 180, 1364–1366 (1973)

    Google Scholar 

  • Moore, R.Y., Björklund, A., Stenevi, U.: Plastic changes in the adrenergic innervation of the rat septal area in response to denervation. Brain Res. 33, 13–35 (1971)

    Google Scholar 

  • Murakami, F., Fujito, Y., Tsukahara, N.: Physiological properties of the newly formed cortico-rubral synapses of red nucleus neurons due to collateral sprouting. Brain Res. 103, 147–151 (1976)

    Google Scholar 

  • Murakami, F., Tsukahara, N., Fujito, Y.: Properties of synaptic transmission of the newly formed cortico-rubral synapses after lesion of the nucleus interpositus of the cerebellum. Exp. Brain Res. 30, 245–258 (1977)

    Google Scholar 

  • Raisman, G.: Neuronal plasticity in the septal nuclei of the adult rat. Brain Res. 14, 15–48 (1969)

    Google Scholar 

  • Raisman, G., Field, P.M.: A quantitative investigation of the developement of collateral reinnervation after partial deafferentation of the septal nuclei. Brain Res. 50, 241–264 (1973)

    Google Scholar 

  • Rall, W.: Theoretical significance of dendritic trees for neuronal input-output relations. In: Neural Theory and Modeling (ed. R.F. Reiss), pp. 73–97. Stanford: Stanford Univ. Press 1964

    Google Scholar 

  • Sato, S., Tsukahara, N.: Some properties of the theoretical membrane transients in Rall's neuron model. J. theor. Biol. 63, 151–163 (1976)

    Google Scholar 

  • Steward, O., Cotman, C.W., Lynch, G.S.: Growth of a new fiber projection in the brain of adult rats: reinnervation of the dentate gyrus by contralateral entorhinal cortex following ipsilateral entorhinal lesions. Exp. Brain Res. 20, 45–66 (1974)

    Google Scholar 

  • Tsukahara, N., Hultborn, H., Murakami, F.: Sprouting of cortico-rubral synapses in red nucleus neurons after destruction of the nucleus interpositus of the cerebellum. Experientia (Basel) 30, 57–58 (1974)

    Google Scholar 

  • Tsukahara, N., Hultborn, H., Murakami, F., Fujito, Y.: Physiological evidence of collateral sprouting and formation of new synapses in the red nucleus following partial denervation. In: Golgi Centennial Symposium Proceedings (ed. M. Santini), pp. 299–303. New York: Raven Press 1975a

    Google Scholar 

  • Tsukahara, N., Hultborn, H., Murakami, F., Fujito, Y.: Electrophysiological study of formation of new synapses and collateral sprouting in red nucleus neurons after partial denervation. J. Neurophysiol. 38, 1359–1372 (1975b)

    Google Scholar 

  • Tsukahara, N., Kosaka, K.: The mode of cerebral excitation of red nucleus neurons. Exp. Brain Res. 5, 102–117 (1968)

    Google Scholar 

  • Tsukahara, N., Murakami, F., Hultborn, H.: Electrical constants of neurons of the red nucleus. Exp. Brain Res. 23, 49–64 (1975c)

    Google Scholar 

  • Wall, P.D., Eggar, M.D.: Formation of new connexions in adult rat brains after partial deafferentation. Nature (London.) 232, 542–545 (1971)

    Google Scholar 

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Authors and Affiliations

  1. Department of Biophysical Engineering, Faculty of Engineering Science, Osaka University, Toyonaka, Osaka, Japan

    F. Murakami, N. Tsukahara & Y. Fujito

Authors
  1. F. Murakami
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  2. N. Tsukahara
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  3. Y. Fujito
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Murakami, F., Tsukahara, N. & Fujito, Y. Analysis of unitary EPSPs mediated by the newly-formed cortico-rubral synapses after lesion of the nucleus interpositus of the cerebellum. Exp Brain Res 30, 233–243 (1977). https://doi.org/10.1007/BF00237253

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  • DOI: https://doi.org/10.1007/BF00237253

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