Summary
In an artificial system, the ionophore A23187, which transports Ca2+ but not Na+, is able to mediate the uphill translocation of Ca2+ from one aqueous medium to another across an organic immiscible phase, provided that a Na+, Li+ or H+ gradient is imposed on the system. Therefore, in the process known as Na-Ca countertransport, the downhill influx of Na+ may not be necessary for causing Ca2+ extrusion against its electrochemical gradient.
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Malaisse, W.J., Anjaneyulu, K., Anjaneyulu, R. et al. Ionophore-mediated Ca2+ countertransport: role of Na+, Li+ or H+ gradient. Mol Cell Biochem 30, 67–70 (1980). https://doi.org/10.1007/BF00227919
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DOI: https://doi.org/10.1007/BF00227919