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Identification of two highly polymorphic CA-repeats (D21S1224 and D21S1261) on human chromosome 21q22.3

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Abstract

Two highly polymorphic CA-repeat microsatellites (D21S1224 and D21S1261) are reported. The clones containing these CA-repeats (ABM-C60 and ABM-C29) have been isolated from a human chromosome-21-specific library (LA21NS01) and have been localised to the q22.3 band using a specific chromosome 21 somatic cell hybrid panel. Both polymorphisms showed heterozygosities of 0.83 in the unrelated reference parents from the Centre d'Etude du Polymorphisme Humain. These new markers should improve the map of the 21q22.3 region, which is believed to contain a large number of genes.

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References

  • Bosch A, Nunes V, Patterson D, Estivill X (1993) Isolation and characterization of fourteen CA-repeat microsatellites from human chromosome 21. Genomics 18:151–155

    Google Scholar 

  • Gardiner K, Watkins P, Munke M, Drabkin H, Jones C, Patterson D (1988) Partial physical map of human chromosome 21. Somat Cell Mol Genet 4:623–638

    Google Scholar 

  • Gardiner K, Horisberger M, Kraus J, Tantravahi U, Korenberg J, Rao V, Reddy S, Patterson D (1990) Correlation of physical and cytogenetic maps; gene and CpG island distributions. EMBO J 9:25–34

    Google Scholar 

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Authors and Affiliations

  1. Molecular Genetics Department, Cancer Research Institute (IRO), Hospital Duran i Reynals, E-08907, L'Hospitalet de Llobregat, Barcelona, Catalunya, Spain

    Assumpció Bosch, Jordi Guimerà & Xavier Estivill

  2. EMBL, Meyerhofstraße 1, D-69117, Heidelberg, Germany

    Stefan Wiemann & Wilhelm Ansorge

  3. Eleanor Roosevelt Institute, 80206, Denver, CO, USA

    David Patterson

Authors
  1. Assumpció Bosch
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  2. Jordi Guimerà
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  3. Stefan Wiemann
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  4. Wilhelm Ansorge
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  5. David Patterson
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  6. Xavier Estivill
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Bosch, A., Guimerà, J., Wiemann, S. et al. Identification of two highly polymorphic CA-repeats (D21S1224 and D21S1261) on human chromosome 21q22.3. Hum Genet 95, 367–369 (1995). https://doi.org/10.1007/BF00225213

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  • DOI: https://doi.org/10.1007/BF00225213

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