Summary
Previous studies have demonstrated that astrocyte processes are responsible for a spontaneously occurring phagocytosis of boutons on cat spinal motoneurons during the second postnatal week. In the present investigation, the astrocytes and the astrocyte processes in contact with the motoneurons were studied qualitatively and quantitatively during the early postnatal period. It could be concluded that the cells responsible for the phagocytosis of boutons are immature astrocytes. These cells were present not only during the period of phagocytosis but also prior to this period. The type of process responsible for the phagocytosis was present not only during the period of phagocytosis but also prior to and after that period although the relative contribution of such processes to the glia-covered membrane area of the motoneurons was reduced in the older animals. On the basis of these results, the possible specificity of the immature astrocyte as the element responsible for the phagocytosis of boutons during normal development is discussed.
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The author is indebted to Miss Maj Berghman, Mrs. Anna-Stina Höijer and Mrs. Lillebil Stuart for excellent technical assistance. This work was supported by grants from Karolinska Institutet and the Swedish Medical Research Council (proj. 2886).
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Ronnevi, LO. Origin of the glial processes responsible for the spontaneous postnatal phagocytosis of boutons on cat spinal motoneurons. Cell Tissue Res. 189, 203–217 (1978). https://doi.org/10.1007/BF00209270
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DOI: https://doi.org/10.1007/BF00209270