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IgA nephropathy in children and adults

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Conclusions

Knowledge concerning IgA nephropathy has expanded greatly in the last 10 years, and its importance as the major form of glomerulonephritis and major contributor to the endstage renal disease is becoming apparent in children and adults. IgA nephropathy is a slowly progressive glomerular disease. Once renal function impairment develops, eventual progression to uremia is inevitable, and so a prophylactic approach to the progression of IgA nephropathy, based on an arbitrary period of therapy early in the course of disease, warrants serious consideration and investigation. A program of urinalysis screening in schools and an appropriate renal biopsy policy make an early diagnosis of IgA nephropathy possible. The development of successful therapy during childhood will offer a great potential for reducing the high morbidity and mortality associated with this disease in adults.

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  1. Department of Pediatrics, Kobe University School of Medicine, 7 Kusunoki-cho, Chuo-ku, Kobe, Japan

    Norishige Yoshikawa & Hajime Nakamura

  2. National Children's Hospital, Tokyo, Japan

    Hiroshi Ito

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  1. Norishige Yoshikawa
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Yoshikawa, N., Nakamura, H. & Ito, H. IgA nephropathy in children and adults. Springer Semin Immunopathol 16, 105–120 (1994). https://doi.org/10.1007/BF00196718

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