Abstract
Gel injection adjustable keratoplasty (GIAK) is a new refractive surgical procedure designed for the correction of myopia by injection of a gel substance into the peripheral corneal stroma. This paper describes the GIAK technique and reports the results obtained in 21 fresh cadaveric eyes using the procedure. After a deep interlamellar canal has been dissected with a helicoid spatula surrounding the visual axis, the gel is injected under keratometric control. In the 1st group of 14 eyes, the degree of correction varied from 2.2 to 12.8 D ; there was a direct relationship between the amount of gel injected and the keratometric change. In the 2nd group of 7 eyes, the adjustability of the procedure was demonstrated. Through partial extraction of the gel and subsequent modification of the corneal curvature, the previously induced keratometric changes could be reversed or altered to a specific extent. Following the initial injection of gel to a targeted flattest meridian power of 35 D, an average value of 35.8 ± 0.5 D was achieved in these eyes. We subsequently attempted to increase the flattest meridian to 40 D by partial removal of the gel and achieved a mean value of 40.2 ± 0.4 D. Average presurgical astigmatism of 1.497 ± 0.737 D was reduced to a postsurgical reading of 0.941 ± 0.590 D (P = 0.005, Student's paired t-test), indicating an autocorrection by autodistribution of the gel inside the canaliculus (Laplace's law). GIAK is a simple, inexpensive procedure designed for the correction of myopia that has the added advantage of reducing preexisting astigmatism without encroaching on the visual axis.
Similar content being viewed by others
References
Barraquer JI (1963) Modificacion de la refraccion por medio de inclusiones intracorneales. Arch Soc Am Oftalmol Optom 4:229–262
Barraquer JI (1964) Queratomileusis para la correccion de la miopia. Arch Soc Am Oftalmol Optom 5:27–48
Barraquer JI (1980) Queratomileusis y Queratofaquia. Instituto Barraquer de America/Editorial Arco, Bogotá
Barraquer JI (1989) Historia de la cirugia refractiva de la cornea. In: Barraquer JI (ed) Cirurgia refractiva de la cornea. Instituto Barraquer de America, Bogota, pp 6–64
Barraquer JI (1989) Cirugia refractiva de la cornea. Instituto Barraquer de America, Bogotá, pp 67–85, 100–107
Beekhuis WH, McCarey BE, Rij G van, Waring GO III (1987) Complications of hydrogel intracorneal lenses in monkeys. Arch Ophthalmol 105:116–122
Belau PG, Dyer JA, Ogle KN, Henderson JW (1964) Correction of ametropia with intracorneal lenses. An experimental study. Arch Ophthalmol 72:541–547
Binder PS, Zavala EY, Deg JK (1983) Hydrogel refractive keratoplasty. Lens removal and exchanges. Cornea 2:119–125
Binder PS, Zavala EY, Deg JK, Baumgartner SD (1984) Alloplastic implants for the correction of refractive errors. Ophthalmology 91:806–814
Binder PS, Zavala EY, Deg JK, Baumgartner SD (1984) Hydrophilic lenses for refractive keratoplasty: the use of factory lathed materials. CLAO J 10:105–111
Blavatskaya ED (1968) Intralamellar homoplasty for the purpose of relaxation of refraction of the eye (transl from Oftalmol Zh 7:530–537). Arch Soc Am Oftalmol Optom 6:311–325
Bourque LB, Cosand BB, Drews C, Waring GO III, Lynn M, Cartwright C (1986) Reported satisfaction, fluctuation of vision, and glare among patients one year after surgery in the Prospective Evaluation of Radial Keratotomy (PERK) study. Arch Ophthalmol 104:356–363
Brown SI, Mishima S (1966) The effect of intralamellar water-impermeable membranes on corneal hydration. Arch Ophthalmol 76:702–708
Choyce DP (1985) Polysulfone corneal inlays to correct refractive errors. Cataract 2(6):6–11
Climenhaga H, MacDonald JM, McCarey BE, Waring GO III (1988) Effect of diameter and depth on the response to solid polysulfone intracorneal lenses in cats. Arch Ophthalmol 106:818–824
Duffey RJ, Tchah H, Lindstrom RL (1989) Human cadaver corneal thinning for experimental refractive surgery. Refractive Corneal Surg 5:41–42
Fleming JF, Reynolds AE, Kilmer L, Burris TE, Abbott RL, Schanzlin DJ (1987) The intrastromal corneal ring: two cases in rabbits. J Refractive Surg 3:227–232
Fleming JF, Lie Wan W, Schanzlin DJ (1989) The theory of corneal curvature change with the intrastromal corneal ring. CLAO J 15:146–150
Gormley DJ, Gersten M, Koplin RS, Lubkin V (1988) Corneal modeling. Cornea 7:30–35
Haefliger E, Parel J-M, Fantes F, Norton EWD, Anderson DR, Forster RF, Herrandez E, Feuer WJ (1987) Accommodation of an endocapsular silicone lens (phaco-ersatz) in the non-human primate. Ophthalmology 94:471–477
Hartman Chr, Ey F von, Abenhaim A, Renard G (1990) Intrastromal implantation of a PMMA-ring for changing corneal refraction. Video presentation at the 1990 EIIC, Dublin, Ireland. Eight Congress of the European Intraocular Implant-lens Council Book of Abstracts, p 154
Hartmann Chr, Pharmakakis N, von Ey F (1989) Intrastromale Implantation eines justierbaren Kunststoffringes zur Hornhautrefraktionsanderung. 3. Kongreβ der Deutschen Gesellschaft für Intraokularlinsen Implantation. Springer, Wien New York
Kim JH, Green K, Martinez M, Paton D (1971) Solute permeability of the corneal endothelium and Descemet's membrane. Exp Eye Res 12:231–238
Koenig SB, Hamano T, Yamaguchi T, Kimura T, McDonald MB, Kaufman HE (1984) Refractive keratoplasty with hydrogel implants in primates. Ophthalmic Surg 15:225–229
Krwawicz T (1961) New plastic operation for correcting the refractive error of aphakic eyes by changing the corneal curvature. Preliminary report. Br J Ophthalmol 45:59–63
Lane SS, Lindstrom RL, Williams PA, Lindstrom CW (1985) Polysulfone intracorneal lenses. J Refractive Surg 1:207–216
Lowery JA, Parel J-M, Roussel TJ (1991) Artificial orbit system for experimental surgery with enucleated globes. Ophthalmic Surg (in press)
Lynn MJ, Waring GO III, Nizam A, Kutner MH, Culbertson W, McDonald MB, Meyers WD, Naidoff MA, Nelson JD, Obstbaum SA, Rowsey JJ, Salz JJ, PERK Study Group (1989) Symmetry of refractive and visual acuity outcome in the Prospective Evaluation of Radial Keratotomy (PERK) study. Refractive Corneal Surg 5:75–81
Mandelbaum S, Waring GO III, Forster RK, Culbertson WW, Rowsey JJ, Espinal ME (1986) Late development of ulcerative keratitis in radial keratotomy scars. Arch Ophthalmol 104:1156–1160
Maurice DM (1967) Nutritional aspects of corneal grafts and prostheses. In: Rycroft PV (ed) Corneo-plastic surgery. Proceedings of the 2nd International Corneo-Plastic Conference held at the Royal College of Surgeons of England, London, July 1967. Pergamon Press, Oxford, pp 197–207
McCarey BE, Andrews DM (1981) Refractive keratoplasty with intrastromal hydrogel lenticular implants. Invest Ophthalmol Vis Sci 21:107–115
McCarey BW, Waring GO III, Street DA (1987) Refractive keratoplasty in monkeys using intracorneal lenses of various refractive indexes. Arch Ophthalmol 105:123–126
Ohrloff C, Duffin RM, Apple DJ, Olson RJ (1984) Opacification, vascularization, and chronic inflammation produced by hydrogel corneal lamellar implants. Am J Ophthalmol 98:422–425
Parel J-M, Parrish RK II, Nose I (1987) An intraoperative intraocular pressure monitor. Ophthalmic Surg 18:371–374
Parel J-M, Simon G, Lowery JA (1990) The effect of wound hydration on central corneal curvature in laser and diamond knife keratotomy. ARVO Abstracts. Invest Ophthalmol Vis Sci 31:479
Patel S (1987) Refractive index of the mammalian cornea and its influence during pachometry. Ophthalmic Physiol Opt 7:503–506
Reader AL III, Salz JJ (1987) Differences among ultrasonic pachymeters in measuring corneal thickness. J Refractive Surg 3:7–11
Sendele DD, Abelson MB, Kenyon KR, Hanninen LA (1983) Intracorneal lens implantation. Arch Ophthalmol 101:940–944
Simon G, Barraquer JI (1988) Queratocricoemfitesis: nuevo procedimiento de cirugia refractiva (estudio experimental). Arch Soc Esp Oftalmol Invest 1:87–93
Simon G, Barraquer RI (1990) Nuevo metodo de cirugia refractiva: anillos intracorneales (estudio experimental). Ann Inst Barraquer 22 (in press)
Simon G, Barraquer RI, Barraquer E (1989) Refractive modeling of the cornea by intrastromal rings. ARVO Abstracts. Invest Ophthalmol Vis Sci 30 [Suppl]:187
Simon G, Parel JM, Nose I, Lee W (1991) Modification, calibration and comparative testing of an automated surgical keratometer. Refractive Corneal Surg 7:151–160
Swinger CA, Kornmehl EW (1985) Dehydration of post-mortem eyes for practice and experimental surgery. Ophthalmic Surg 16:182–183
Thompson KP, Hanna K, Waring GO III (1989) Emerging technologies for refractive surgery: laser adjustable synthetic epikeratoplasty. Refractive Corneal Surg 5:46–48
Troutman RC, Swinger C (1978) Refractive keratoplasty: keratophakia and keratomileusis. Trans Am Ophthalmol Soc 76:329–339
Werblin TP, Peiffer RL, Patel AS (1987) Synthetic keratophakia for the correction of aphakia. Ophthalmology 94:926–934
Author information
Authors and Affiliations
Additional information
Presented in part at the meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Florida, on May 2, 1990. This investigation was supported in part by the Florida Lions Eye Bank, Miami, Florida; the Helena Rubinstein Foundation, New York; the Veterans Administration Medical Center, Miami, Florida; and by Public Health Service Research grants EY02180, Department of Health and Human Services, National Institutes of Health, National Eye Institute, Bethesda, Maryland. The authors have no proprietary or financial interest in any of the devices mentioned herein. The University of Miami has proprietary and financial interests in the procedure described
Offprint requests to: J.-M. Parel
Rights and permissions
About this article
Cite this article
Simon, G., Parel, JM., Lee, W. et al. Gel injection adjustable keratoplasty. Graefe's Arch Clin Exp Ophthalmol 229, 418–424 (1991). https://doi.org/10.1007/BF00166303
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00166303