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Gel injection adjustable keratoplasty

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Abstract

Gel injection adjustable keratoplasty (GIAK) is a new refractive surgical procedure designed for the correction of myopia by injection of a gel substance into the peripheral corneal stroma. This paper describes the GIAK technique and reports the results obtained in 21 fresh cadaveric eyes using the procedure. After a deep interlamellar canal has been dissected with a helicoid spatula surrounding the visual axis, the gel is injected under keratometric control. In the 1st group of 14 eyes, the degree of correction varied from 2.2 to 12.8 D ; there was a direct relationship between the amount of gel injected and the keratometric change. In the 2nd group of 7 eyes, the adjustability of the procedure was demonstrated. Through partial extraction of the gel and subsequent modification of the corneal curvature, the previously induced keratometric changes could be reversed or altered to a specific extent. Following the initial injection of gel to a targeted flattest meridian power of 35 D, an average value of 35.8 ± 0.5 D was achieved in these eyes. We subsequently attempted to increase the flattest meridian to 40 D by partial removal of the gel and achieved a mean value of 40.2 ± 0.4 D. Average presurgical astigmatism of 1.497 ± 0.737 D was reduced to a postsurgical reading of 0.941 ± 0.590 D (P = 0.005, Student's paired t-test), indicating an autocorrection by autodistribution of the gel inside the canaliculus (Laplace's law). GIAK is a simple, inexpensive procedure designed for the correction of myopia that has the added advantage of reducing preexisting astigmatism without encroaching on the visual axis.

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References

  1. Barraquer JI (1963) Modificacion de la refraccion por medio de inclusiones intracorneales. Arch Soc Am Oftalmol Optom 4:229–262

    Google Scholar 

  2. Barraquer JI (1964) Queratomileusis para la correccion de la miopia. Arch Soc Am Oftalmol Optom 5:27–48

    Google Scholar 

  3. Barraquer JI (1980) Queratomileusis y Queratofaquia. Instituto Barraquer de America/Editorial Arco, Bogotá

    Google Scholar 

  4. Barraquer JI (1989) Historia de la cirugia refractiva de la cornea. In: Barraquer JI (ed) Cirurgia refractiva de la cornea. Instituto Barraquer de America, Bogota, pp 6–64

    Google Scholar 

  5. Barraquer JI (1989) Cirugia refractiva de la cornea. Instituto Barraquer de America, Bogotá, pp 67–85, 100–107

    Google Scholar 

  6. Beekhuis WH, McCarey BE, Rij G van, Waring GO III (1987) Complications of hydrogel intracorneal lenses in monkeys. Arch Ophthalmol 105:116–122

    Google Scholar 

  7. Belau PG, Dyer JA, Ogle KN, Henderson JW (1964) Correction of ametropia with intracorneal lenses. An experimental study. Arch Ophthalmol 72:541–547

    Google Scholar 

  8. Binder PS, Zavala EY, Deg JK (1983) Hydrogel refractive keratoplasty. Lens removal and exchanges. Cornea 2:119–125

    Google Scholar 

  9. Binder PS, Zavala EY, Deg JK, Baumgartner SD (1984) Alloplastic implants for the correction of refractive errors. Ophthalmology 91:806–814

    Google Scholar 

  10. Binder PS, Zavala EY, Deg JK, Baumgartner SD (1984) Hydrophilic lenses for refractive keratoplasty: the use of factory lathed materials. CLAO J 10:105–111

    Google Scholar 

  11. Blavatskaya ED (1968) Intralamellar homoplasty for the purpose of relaxation of refraction of the eye (transl from Oftalmol Zh 7:530–537). Arch Soc Am Oftalmol Optom 6:311–325

    Google Scholar 

  12. Bourque LB, Cosand BB, Drews C, Waring GO III, Lynn M, Cartwright C (1986) Reported satisfaction, fluctuation of vision, and glare among patients one year after surgery in the Prospective Evaluation of Radial Keratotomy (PERK) study. Arch Ophthalmol 104:356–363

    Google Scholar 

  13. Brown SI, Mishima S (1966) The effect of intralamellar water-impermeable membranes on corneal hydration. Arch Ophthalmol 76:702–708

    Google Scholar 

  14. Choyce DP (1985) Polysulfone corneal inlays to correct refractive errors. Cataract 2(6):6–11

    Google Scholar 

  15. Climenhaga H, MacDonald JM, McCarey BE, Waring GO III (1988) Effect of diameter and depth on the response to solid polysulfone intracorneal lenses in cats. Arch Ophthalmol 106:818–824

    Google Scholar 

  16. Duffey RJ, Tchah H, Lindstrom RL (1989) Human cadaver corneal thinning for experimental refractive surgery. Refractive Corneal Surg 5:41–42

    Google Scholar 

  17. Fleming JF, Reynolds AE, Kilmer L, Burris TE, Abbott RL, Schanzlin DJ (1987) The intrastromal corneal ring: two cases in rabbits. J Refractive Surg 3:227–232

    Google Scholar 

  18. Fleming JF, Lie Wan W, Schanzlin DJ (1989) The theory of corneal curvature change with the intrastromal corneal ring. CLAO J 15:146–150

    Google Scholar 

  19. Gormley DJ, Gersten M, Koplin RS, Lubkin V (1988) Corneal modeling. Cornea 7:30–35

    Google Scholar 

  20. Haefliger E, Parel J-M, Fantes F, Norton EWD, Anderson DR, Forster RF, Herrandez E, Feuer WJ (1987) Accommodation of an endocapsular silicone lens (phaco-ersatz) in the non-human primate. Ophthalmology 94:471–477

    Google Scholar 

  21. Hartman Chr, Ey F von, Abenhaim A, Renard G (1990) Intrastromal implantation of a PMMA-ring for changing corneal refraction. Video presentation at the 1990 EIIC, Dublin, Ireland. Eight Congress of the European Intraocular Implant-lens Council Book of Abstracts, p 154

  22. Hartmann Chr, Pharmakakis N, von Ey F (1989) Intrastromale Implantation eines justierbaren Kunststoffringes zur Hornhautrefraktionsanderung. 3. Kongreβ der Deutschen Gesellschaft für Intraokularlinsen Implantation. Springer, Wien New York

    Google Scholar 

  23. Kim JH, Green K, Martinez M, Paton D (1971) Solute permeability of the corneal endothelium and Descemet's membrane. Exp Eye Res 12:231–238

    Google Scholar 

  24. Koenig SB, Hamano T, Yamaguchi T, Kimura T, McDonald MB, Kaufman HE (1984) Refractive keratoplasty with hydrogel implants in primates. Ophthalmic Surg 15:225–229

    Google Scholar 

  25. Krwawicz T (1961) New plastic operation for correcting the refractive error of aphakic eyes by changing the corneal curvature. Preliminary report. Br J Ophthalmol 45:59–63

    Google Scholar 

  26. Lane SS, Lindstrom RL, Williams PA, Lindstrom CW (1985) Polysulfone intracorneal lenses. J Refractive Surg 1:207–216

    Google Scholar 

  27. Lowery JA, Parel J-M, Roussel TJ (1991) Artificial orbit system for experimental surgery with enucleated globes. Ophthalmic Surg (in press)

  28. Lynn MJ, Waring GO III, Nizam A, Kutner MH, Culbertson W, McDonald MB, Meyers WD, Naidoff MA, Nelson JD, Obstbaum SA, Rowsey JJ, Salz JJ, PERK Study Group (1989) Symmetry of refractive and visual acuity outcome in the Prospective Evaluation of Radial Keratotomy (PERK) study. Refractive Corneal Surg 5:75–81

    Google Scholar 

  29. Mandelbaum S, Waring GO III, Forster RK, Culbertson WW, Rowsey JJ, Espinal ME (1986) Late development of ulcerative keratitis in radial keratotomy scars. Arch Ophthalmol 104:1156–1160

    Google Scholar 

  30. Maurice DM (1967) Nutritional aspects of corneal grafts and prostheses. In: Rycroft PV (ed) Corneo-plastic surgery. Proceedings of the 2nd International Corneo-Plastic Conference held at the Royal College of Surgeons of England, London, July 1967. Pergamon Press, Oxford, pp 197–207

    Google Scholar 

  31. McCarey BE, Andrews DM (1981) Refractive keratoplasty with intrastromal hydrogel lenticular implants. Invest Ophthalmol Vis Sci 21:107–115

    Google Scholar 

  32. McCarey BW, Waring GO III, Street DA (1987) Refractive keratoplasty in monkeys using intracorneal lenses of various refractive indexes. Arch Ophthalmol 105:123–126

    Google Scholar 

  33. Ohrloff C, Duffin RM, Apple DJ, Olson RJ (1984) Opacification, vascularization, and chronic inflammation produced by hydrogel corneal lamellar implants. Am J Ophthalmol 98:422–425

    Google Scholar 

  34. Parel J-M, Parrish RK II, Nose I (1987) An intraoperative intraocular pressure monitor. Ophthalmic Surg 18:371–374

    Google Scholar 

  35. Parel J-M, Simon G, Lowery JA (1990) The effect of wound hydration on central corneal curvature in laser and diamond knife keratotomy. ARVO Abstracts. Invest Ophthalmol Vis Sci 31:479

    Google Scholar 

  36. Patel S (1987) Refractive index of the mammalian cornea and its influence during pachometry. Ophthalmic Physiol Opt 7:503–506

    Google Scholar 

  37. Reader AL III, Salz JJ (1987) Differences among ultrasonic pachymeters in measuring corneal thickness. J Refractive Surg 3:7–11

    Google Scholar 

  38. Sendele DD, Abelson MB, Kenyon KR, Hanninen LA (1983) Intracorneal lens implantation. Arch Ophthalmol 101:940–944

    Google Scholar 

  39. Simon G, Barraquer JI (1988) Queratocricoemfitesis: nuevo procedimiento de cirugia refractiva (estudio experimental). Arch Soc Esp Oftalmol Invest 1:87–93

    Google Scholar 

  40. Simon G, Barraquer RI (1990) Nuevo metodo de cirugia refractiva: anillos intracorneales (estudio experimental). Ann Inst Barraquer 22 (in press)

  41. Simon G, Barraquer RI, Barraquer E (1989) Refractive modeling of the cornea by intrastromal rings. ARVO Abstracts. Invest Ophthalmol Vis Sci 30 [Suppl]:187

    Google Scholar 

  42. Simon G, Parel JM, Nose I, Lee W (1991) Modification, calibration and comparative testing of an automated surgical keratometer. Refractive Corneal Surg 7:151–160

    Google Scholar 

  43. Swinger CA, Kornmehl EW (1985) Dehydration of post-mortem eyes for practice and experimental surgery. Ophthalmic Surg 16:182–183

    Google Scholar 

  44. Thompson KP, Hanna K, Waring GO III (1989) Emerging technologies for refractive surgery: laser adjustable synthetic epikeratoplasty. Refractive Corneal Surg 5:46–48

    Google Scholar 

  45. Troutman RC, Swinger C (1978) Refractive keratoplasty: keratophakia and keratomileusis. Trans Am Ophthalmol Soc 76:329–339

    Google Scholar 

  46. Werblin TP, Peiffer RL, Patel AS (1987) Synthetic keratophakia for the correction of aphakia. Ophthalmology 94:926–934

    Google Scholar 

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Presented in part at the meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Florida, on May 2, 1990. This investigation was supported in part by the Florida Lions Eye Bank, Miami, Florida; the Helena Rubinstein Foundation, New York; the Veterans Administration Medical Center, Miami, Florida; and by Public Health Service Research grants EY02180, Department of Health and Human Services, National Institutes of Health, National Eye Institute, Bethesda, Maryland. The authors have no proprietary or financial interest in any of the devices mentioned herein. The University of Miami has proprietary and financial interests in the procedure described

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Simon, G., Parel, JM., Lee, W. et al. Gel injection adjustable keratoplasty. Graefe's Arch Clin Exp Ophthalmol 229, 418–424 (1991). https://doi.org/10.1007/BF00166303

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  • DOI: https://doi.org/10.1007/BF00166303

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