Abstract
Antibodies to HTLV-III were found in 6 of 206 Sicilian patients with thalassemia major, aged 1 to 30 years. None of the patients showed clinical signs related to immuno-deficiency syndromes. Immunological investigations carried out in all positive patients showed alterations similar to those found in thalassemic patients without antibodies to HTLV-III. These immunological changes could not depend on the HTLV-III infection, but could be related to the thalassemic condition.
References
Amman A.J., Cowan M.J., Wara D.W., Weintrub P., Dritz S., Goldman H., Perkins H. (1983): Acquired immunodeficiency in an infant: possible transmission by means of blood products. - Lancet ii: 956–958.
Boiteux F., Vilmer E., Girot R., Muller J.Y., Rouzioux C., Chamaret S., Montagnier L. (1985): Lymphoadenopathy syndrome in two thalassemic patients after LAV contamination by blood products. -New Engl. J. Med. 312: 648–649.
Boyum A. (1968): Separation of leukocytes from blood and bone marrow. Scandinavian Journal of Clin. Labor. Invest. 21 suppl. 97, 77–89.
Church J.A., Isaacs H. (1984): Transfusion-associated acquired immunodeficiency syndromes in infants. - J. Pediatr. 105: 731–737.
Curran J.W., Lawrence D.N., Jaffe H.J. et al. (1984): Acquired immune deficiency syndrome (AIDS) associated with transfusions. - New Engl. J. Med. 310: 69–75.
De Martino M., Rossi M.E., Muccioli A.T., Vullo V., Vierucci A. (1985): Altered T cell subsets and function in polytransfused β-thalassemia patients: correlation with sex and age at first transfusion. -Vox Sang. 48: 296–304.
De Martino M., Quarta G., Melpignano A., Guadalupi C., Vullo C., Ferrucci M., Vierucci A. (1985): Antibodies to HTLV-III and the lymphoadenopathy syndrome in multitransfused β-thalassemic patients. -Vox Sang. 49: 230–233.
Gill J.C., Menitove J.E., Wheeler D., Aster R.H., Montgomery R.R. (1983): Generalized lymphoadenopathy and T cell abnormalities in hemophilia. -Am. J. Pediat. 103: 18–22.
Jones P., Proctor S., Dickinson A., George S. (1983): Altered immunology in hemophilia. - Lancet i: 120–121.
Lederman M.M., Ratnoff O.D., Sicilian J.J., Jones P.K., Schacter B. (1983): Impaired cell-mediated immunity in patients with classic hemophilia. -New Engl. J. Med. 308: 79–83.
Melief C.J.M., Goudsmit J. (1986): Transmission of lymphotropic retroviruses (HTLV-I and LAV/HTLV-III) by blood transfusion and blood products. -Vox Sang. 50: 1–11.
Musumeci S., Schilirò G., Romeo M.A., Sciotto A., Rosalba A., Pizzarelli G. (1979): Lymphocyte changes in β-thalassemia major. - Arch. - Dis. Childh. 54: 954–957.
Shannon K., Ball E., Wasserman R.L., Murphy F.K., Luby J., Buchanan G. (1983): Transfusion-associated cytomegalovirus infection and acquired immune deficiency syndrome in an infant. - J. Pediatr. 103: 859–863.
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Romeo, M.A., Russo Mancuso, G., Mauro, L. et al. Immunological changes in β-thalassemia major patients positive for HTLV-III antibodies. Eur J Epidemiol 3, 451–453 (1987). https://doi.org/10.1007/BF00145663
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DOI: https://doi.org/10.1007/BF00145663