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Chirality Revealed by Raman Optical Activity: Principles, Applications, Recent Developments and Future Prospects

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Raman Spectroscopy

Part of the book series: Springer Series in Optical Sciences ((SSOS,volume 248))

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Abstract

Chirality is a fundamental property of molecules, particularly important in biological systems. The ability to distinguish between enantiomers is crucial in many fields. Raman optical activity (ROA) is a powerful analytical technique that measures the small intensity difference in Raman scattering of right- and left-circularly polarized light by chiral molecules. Due to their sensitivity to stereochemistry, ROA spectra can provide an ample amount of information on both structure and conformational behavior of chiral molecules. Here we present the theoretical background to the subject and an overview of different forms of ROA measurement, including resonance ROA (RROA) and surface-enhanced ROA (SEROA). We also discuss the application of ROA spectroscopy to a variety of molecules, emphasizing the extent of structural information that can be gathered. Although ROA is still a specialized technique, recent advances have led to several new applications and developments. We show several results to illustrate how ROA is opening new opportunities in analytical chemistry. Finally, we discuss recent advances in ROA instrumentation and its advantages and limitations compared to other chiral spectroscopic techniques, such as electronic and vibrational circular dichroism. Hopefully, this chapter provides a comprehensive list of the fundamentals, applications, advancements, and future potential of ROA as a powerful analytical technique for exploring and studying chirality in molecules.

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Authors and Affiliations

  1. Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo náměstí 2, 16610, Prague, Czech Republic

    Moumita Das, Andrii Kurochka, Petr Bouř & Debraj Gangopadhyay

  2. Department of Analytical Chemistry, University of Chemistry and Technology, Technická 5, 16628, Prague, Czech Republic

    Moumita Das & Petr Bouř

Authors
  1. Moumita Das
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  2. Andrii Kurochka
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  3. Petr Bouř
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  4. Debraj Gangopadhyay
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Correspondence to Debraj Gangopadhyay .

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Editors and Affiliations

  1. School of Nano Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India

    Dheeraj Kumar Singh

  2. School of Materials Science and Technology, Indian Institute of Technology (BHU), Varanasi, India

    Ashish Kumar Mishra

  3. School of Science, Constructor University, Bremen, Bremen, Germany

    Arnulf Materny

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Das, M., Kurochka, A., Bouř, P., Gangopadhyay, D. (2024). Chirality Revealed by Raman Optical Activity: Principles, Applications, Recent Developments and Future Prospects. In: Singh, D.K., Kumar Mishra, A., Materny, A. (eds) Raman Spectroscopy. Springer Series in Optical Sciences, vol 248. Springer, Singapore. https://doi.org/10.1007/978-981-97-1703-3_7

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