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Nanocarriers in Protein and Peptide Drug Delivery

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Nanocarriers: Drug Delivery System

Abstract

Protein and peptide are biomolecules that determine and control biological functions, thereby playing a significant role in treating various pathological conditions. Current research focuses on the development of dosage form for efficient delivery of proteins and peptides. Characteristics of biomolecules make them challenging therapeutic agents to formulate and to deliver. Stability of protein and peptide molecules is a preliminary requirement, ranging from development of dosage form to availability of drug at the site of action. The most convenient oral route is not suitable to deliver protein and peptide molecules due to poor stability of drug in harsh gastric environment. Parenteral route has the potential application to deliver biomolecules, and circumvent drawbacks associated with oral delivery of proteins and peptides. Parenteral route can elicit pharmacological action even with minimal dose of drug, preserving the integrity of molecules. To overcome the drawback of short half-life and patient compliance, associated with intravenous route, an alternate route has also been developed to deliver drugs. Extensive studies have been conducted to deliver protein and peptide molecules effectively using various delivery systems. Among a variety of systems, nanocarriers have emerged as a compelling tool due to very fine particle size, flexibility with a variety of dosage forms and routes of administration, and long circulatory half-life due to avoidance by reticular endothelial system. Further, nanocarriers can also deal with targeted and site-specific drug delivery. Physicochemical properties of biomolecules play a vital role in the selection of polymer, method of preparation, kind of carrier molecules, and drug delivery system to be used.

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Author information

Authors and Affiliations

  1. Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Vadodara, Gujarat, India

    Dipti Gohil

  2. International Research Centre, Kalasalingam Academy of Research and Education (Deemed University), Krishnankoil, Tamil Nadu, India

    Theivasanthi Thirugnanasambandan

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  1. Dipti Gohil
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  2. Theivasanthi Thirugnanasambandan
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Correspondence to Dipti Gohil .

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Editors and Affiliations

  1. Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India

    Nirmal Shah

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Gohil, D., Thirugnanasambandan, T. (2021). Nanocarriers in Protein and Peptide Drug Delivery. In: Shah, N. (eds) Nanocarriers: Drug Delivery System. Springer, Singapore. https://doi.org/10.1007/978-981-33-4497-6_14

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