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Current Advances in Nanotechnology and Medicine

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NanoBioMedicine

Abstract

One of the most imperative questions that arise is why we are indulging ourselves in nanotechnology and medicine. The rationale is its size in nanometer range which makes it easy to enter into cells of human body making it beneficial for special types of cell target therapy such as efficient delivery of drugs to the target cell and competent detection of diseases. Studies have come up with one more beneficial factor, that is, the nanoparticles can also protect drug from degradation because of the shield-like properties. The elemental proposition upon which nanomedicine is pursued is nanoparticles, which are introduced into the body as foreign bodies and are subjected to the full armory of the body’s defense system labeled with antibody molecules targeting specific cells. Diverse types and forms of nanoparticles are used in medicine. Advances in the area of nanomedicine have come a long way since the time it was envisioned to be studied. The objectives and goal to establish global roadmaps in nanomedicine are guided by the need to take care of life-threatening clinical issues. Nanomedicine has a potential to combat several human diseases including cancer as well as infectious, neurological, musculoskeletal, cardiovascular diseases. In this chapter we will be discussing the ongoing progress of nanotechnology and its application in various fields of medicine.

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References

  • Akbarzadeh A, Rezaei-Sadabady R, Davaran S, Joo SW, Zarghami N, Hanifehpour Y, Samiei M, Kouhi M, Nejati-Koshki K (2013) Liposome: classification, preparation, and applications. Nanoscale Res Lett 8(1):102

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Archakov AI (2010) Nanobiotechnologies in medicine: nanodiagnostics and nanodrugs. Biomed Khim 56(1):7–25

    CAS  PubMed  Google Scholar 

  • Baptista PV (2014) Nanodiagnostics: leaving the research lab to enter the clinics? Diagnosis (Berl) 4:305–309

    Article  Google Scholar 

  • Bawage SS, Tiwari PM, Pillai S, Dennis V, Singh SR (2013) Recent advances in diagnosis, prevention, and treatment of human respiratory syncytial virus. Adv Virol 2013:595768

    Article  PubMed  PubMed Central  Google Scholar 

  • Bayford R, Rademacher T, Roitt I, Wang SX (2017) Emerging applications of nanotechnology for diagnosis and therapy of disease: a review. Physiol Meas 38(8):R183–R203

    Article  PubMed  Google Scholar 

  • Biswaro LS, da Costa Sousa MG, Rezende TMB, Dias SC, Franco OL (2018) Antimicrobial peptides and nanotechnology, recent advances and challenges. Front Microbiol 9:855

    Article  PubMed  PubMed Central  Google Scholar 

  • Cardoso VF, Francesko A, Ribeiro C, Bañobre-López M, Martins P, Lanceros-Mendez S (2018) Advances in magnetic nanoparticles for biomedical applications. Adv Healthc Mater 7(5): 1–35, 1700845

    Google Scholar 

  • Castro E, Kumar A (2013) Nanoparticles in drug delivery systems. In: Nanomedicine in drug delivery. pp 1–22

    Google Scholar 

  • Cattel L, Ceruti M, Dosio F (2003) From conventional to stealth liposomes: a new frontier in cancer chemotherapy. Tumori 89(3):237–249

    Article  CAS  PubMed  Google Scholar 

  • Cole LE, Ross RD, Tilley JM, Vargo-Gogola T, Roeder RK (2015) Gold nanoparticles as contrast agents in x-ray imaging and computed tomography. Nanomedicine (Lond) 10(2):321–341

    Article  CAS  Google Scholar 

  • Date T, Nimbalkar V, Kamat J, Mittal A, Mahato RI, Chitkara D (2018) Lipid-polymer hybrid nanocarriers for delivering cancer therapeutics. J Control Release 271:60–73

    Article  CAS  PubMed  Google Scholar 

  • DiSanto RM, Subramanian V, Gu Z (2015). Recent advances in nanotechnology for diabetes treatment. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 7(4): 548–564

    Google Scholar 

  • Emeto TI, Alele FO, Smith AM, Smith FM, Dougan T, Golledge J (2017) Use of nanoparticles as contrast agents for the functional and molecular imaging of Abdominal Aortic Aneurysm. Front Cardiovasc Med 4:16

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Fumakia M, Ho EA (2016) Nanoparticles encapsulated with LL37 and Serpin A1 promotes wound healing and synergistically enhances antibacterial activity. Mol Pharm 13(7):2318–2331

    Article  CAS  PubMed  Google Scholar 

  • Goldman LW (2007) Principles of CT and CT technology. J Nucl Med Technol 35(3):115–128

    Article  PubMed  Google Scholar 

  • Jain KK (2008) Nanomedicine: application of nanobiotechnology in medical practice. Med Princ Pract 17(2):89–101

    Article  CAS  PubMed  Google Scholar 

  • Jones T, Townsend D (2017) History and future technical innovation in positron emission tomography. J Med Imaging (Bellingham) 4(1):011013

    Article  Google Scholar 

  • Kim D, Kim J, Park YI, Lee N, Hyeon T (2018) Recent development of inorganic nanoparticles for biomedical imaging. ACS Cent Sci 4(3):324–336

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kumar S, Maurya VK, Dandu HR, Bhatt ML, Saxena SK (2018) Global perspective of novel therapeutic strategies for the management of NeuroAIDS. Biomol Concepts 9(1):33–42

    Article  CAS  PubMed  Google Scholar 

  • Logothetidis S (2006) Nanotechnology in medicine: the medicine of tomorrow and nanomedicine. Hippokratia 10(1):7–21

    Google Scholar 

  • Madni A, Tahir N, Rehman M, Raza A, Mahmood MA, Khan MI, Kashif PM (2017) Hybrid Nano-carriers for potential drug delivery. Adv Technol Deliv Ther (Book): 53–87. https://doi.org/10.5772/66466. IntechOpen

  • Matea CT, Mocan T, Tabaran F, Pop T, Mosteanu O, Puia C, Iancu C, Mocan L (2017) Quantum dots in imaging, drug delivery and sensor applications. Int J Nanomed 12:5421–5431

    Article  CAS  Google Scholar 

  • Mieszawska AJ, Mulder WJ, Fayad ZA, Cormode DP (2013) Multifunctional gold nanoparticles for diagnosis and therapy of disease. Mol Pharm 10(3):831–847

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Miller AD (2016) Nanomedicine therapeutics and diagnostics are the goal. Ther Deliv 7(7):431–456

    Article  CAS  PubMed  Google Scholar 

  • Misra R, Acharya S, Sahoo SK (2010) Cancer nanotechnology: application of nanotechnology in cancer therapy. Drug Discov Today 15(19–20):842–850

    Article  CAS  PubMed  Google Scholar 

  • Naseri N, Ajorlou E, Asghari F, Pilehvar-Soltanahmadi Y (2018) An update on nanoparticle-based contrast agents in medical imaging. Artif Cells Nanomed Biotechnol 46(6):1111–1121

    Article  CAS  PubMed  Google Scholar 

  • Okada H, Toguchi H (1995) Critical reviews in therapeutic drug carrier systems. Crit Rev Ther Drug Carr Syst 12(1):1–99

    Article  CAS  Google Scholar 

  • Olusanya T, Haj Ahmad R, Ibegbu D, Smith J, Elkordy A (2018) Liposomal drug delivery systems and anticancer drugs. Molecules 23(4):907

    Article  PubMed Central  CAS  Google Scholar 

  • Pan S, Yu H, Yang X, Yang X, Wang Y, Liu Q, Jin L, Yang Y (2017) Application of nanomaterials in stem cell regenerative medicine of orthopedic surgery. J Nanomater 2017:1–12, 1985942

    Google Scholar 

  • Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MDP, Acosta-Torres LS, Diaz-Torres LA, Grillo R, Swamy MK, Sharma S, Habtemariam S, Shin HS (2018) Nanobased drug delivery systems: recent developments and future prospects. J Nanobiotechnol 16(1):71

    Article  CAS  Google Scholar 

  • Rizvi SA, Saleh AM (2018) Applications of nanoparticle systems in drug delivery technology. Saudi Pharm J 26(1):64–70

    Article  PubMed  Google Scholar 

  • Rizzo LY, Theek B, Storm G, Kiessling F, Lammers T (2013) Recent progress in nanomedicine: therapeutic, diagnostic and theranostic applications. Curr Opin Biotechnol 24(6):1159–1166

    Article  CAS  PubMed  Google Scholar 

  • Sands MJ, Levitin A (2004) Basics of magnetic resonance imaging. Semin Vasc Surg 17(2):66–82

    Article  PubMed  Google Scholar 

  • Saxena SK, Tiwari S, Nair MP (2012) Nanotherapeutics: emerging competent technology in neuroAIDS and CNS drug delivery. Nanomedicine (Lond) 7(7):941–944

    Article  CAS  Google Scholar 

  • Serda RE, Godin B, Blanco E, Chiappini C, Ferrari M (2011) Multi-stage delivery nano-particle systems for therapeutic applications. Biochim Biophys Acta 1810(3):317–329

    Article  CAS  PubMed  Google Scholar 

  • Silindir M, Özer AY, Erdoğan S (2012) The use and importance of liposomes in positron emission tomography. Drug Deliv 19(1):68–80

    Article  CAS  PubMed  Google Scholar 

  • Singh L, Kruger HG, Maguire GEM, Govender T, Parboosing R (2017) The role of nanotechnology in the treatment of viral infections. Ther Adv Infect Dis 4(4):105–131

    CAS  PubMed  PubMed Central  Google Scholar 

  • Suri SS, Fenniri H, Singh B (2007) Nanotechnology-based drug delivery systems. J Occup Med Toxicol 2(1):16

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tognarelli JM, Dawood M, Shariff MI, Grover VP, Crossey MM, Cox IJ, Taylor-Robinson SD, McPhail MJ (2015) Magnetic resonance spectroscopy: principles and techniques: lessons for clinicians. J Clin Exp Hepatol 5(4):320–328

    Article  PubMed  PubMed Central  Google Scholar 

  • Van Rijt S, Habibovic P (2017) Enhancing regenerative approaches with nanoparticles. J R Soc Interface 14(129). pii: 20170093

    Google Scholar 

  • Wang YF, Liu L, Xue X, Liang XJ (2017) Nanoparticle-based drug delivery systems: what can they really do in vivo? F1000Res 6:681

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Woldu MA, Lenjisa JL (2015) Nanoparticles and the new era in diabetes management. Int J Basic Clin Pharmacol 2014(3):277–284

    Google Scholar 

  • Xie F, Xie L (2018) Serum zinc level is associated with liver dysfunction caused by white smoke inhalation. Gastroenterol Rep 6(4):304–307

    Article  Google Scholar 

  • Yu X, Trase I, Ren M, Duval K, Guo X, Chen Z (2016) Design of Nanoparticle-Based Carriers for targeted drug delivery. J Nanomater. pii: 1087250

    Google Scholar 

  • Zhang H, Yee D, Wang C (2008a) Quantum dots for cancer diagnosis and therapy: biological and clinical perspectives. Nanomedicine (Lond) 3(1):83–91

    Article  CAS  Google Scholar 

  • Zhang L, Gu FX, Chan JM, Wang AZ, Langer RS, Farokhzad OC (2008b) Nanoparticles in medicine: therapeutic applications and developments. Clin Pharmacol Ther 83(5):761–769

    Article  CAS  PubMed  Google Scholar 

  • Zhang W, Wang W, Yu DX, Xiao Z, He Z (2018a) Application of nanodiagnostics and nanotherapy to CNS diseases. Nanomedicine (Lond) 13(18):2341–2371

    Article  CAS  Google Scholar 

  • Zhang H, Liu XL, Zhang YF, Gao F, Li GL, He Y, Peng ML, Fan HM (2018b) Magnetic nanoparticles based cancer therapy: current status and applications. Sci China Life Sci 61(4):400–414

    Article  CAS  PubMed  Google Scholar 

  • Zhao CY, Cheng R, Yang Z, Tian ZM (2018a) Nanotechnology for Cancer Therapy Based on Chemotherapy. Molecules 23(4). pii: E826

    Google Scholar 

  • Zhao N, Woodle MC, Mixson AJ (2018b) Advances in delivery systems for doxorubicin. J Nanomed Nanotechnol 9(5). pii: 519

    Google Scholar 

  • Zitka O, Ryvolova M, Hubalek J, Eckschlager T, Adam V, Kizek R (2012) From amino acids to proteins as targets for metal-based drugs. Curr Drug Metab 13(3):306–320

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The authors are grateful to the Vice Chancellor, King George’s Medical University (KGMU), Lucknow, for the encouragement and support for this work. SK Saxena is also supported by CCRH, Government of India, and US NIH grants: R37DA025576 and R01MH085259. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

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Correspondence to Shailendra K. Saxena .

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Saxena, S.K., Nyodu, R., Kumar, S., Maurya, V.K. (2020). Current Advances in Nanotechnology and Medicine. In: Saxena, S., Khurana, S. (eds) NanoBioMedicine. Springer, Singapore. https://doi.org/10.1007/978-981-32-9898-9_1

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