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HDL and Scavenger Receptor Class B Type I (SRBI)

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HDL Metabolism and Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1377))

Abstract

The scavenger receptor class B type I (SR-BI) is a versatile HDL receptor protein. It is highly expressed in liver and steroidogenic tissues. SR-BI regulates selective uptake of cholesterol ester (CE) from HDL, revealing its role in mediating reverse cholesterol transport (RCT) and steroid hormone synthesis. In addition, SR-BI is involved in cholesterol transport, cellular inflammatory response, platelet reactivity, and HDL-initiated signaling in the vascular system in several mouse models. Mutations in the human SR-BI gene (SCARB1) have been found to be associated with abnormally high plasma HDL-C levels and an increased risk of atherosclerotic cardiovascular disease. At present, the key regions of SR-BI transmembrane structure and the regulatory mechanisms of SR-BI expression still need to be further studied. In this chapter, the structural, functional, and regulatory characteristics of SR-BI are reviewed, and the importance of SR-BI in related metabolic diseases was expounded.

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  1. Wuhan University School of Basic Medical Sciences, Wuhan, Hubei, China

    Hong Yu

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Correspondence to Hong Yu .

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  1. Institute of Cardiovascular Sciences, Peking University, Beijing, China

    Lemin Zheng

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Yu, H. (2022). HDL and Scavenger Receptor Class B Type I (SRBI). In: Zheng, L. (eds) HDL Metabolism and Diseases. Advances in Experimental Medicine and Biology, vol 1377. Springer, Singapore. https://doi.org/10.1007/978-981-19-1592-5_6

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