Abstract
Nanotechnology is an emergent field of research and innovation applied to nanoelectronics, nanomaterials, nanobiology, nanomedicine, among other areas. Particularly in medicine it has been used to improve the disease diagnosis through novel instrumentation as well as the treatment efficacy through the encapsulation and controlled release of bioactive compounds. Overall, nanotechnology can provide novel tools and techniques to biomedical research, namely in proteomics, genetics and regenerative medicine. Polymer nanofibers are one of the nanostructures that have been used in nanomedicine, especially those fabricated by electrospinning. The development of drug delivery systems, wound dressing materials, tissue regeneration and disease diagnosis are the most representative examples about the use of electrospun nanofibers. Their use in medical microbiology has mostly contributed to an improvement in the treatment of microbial infections through the increase of response capacity of active pharmaceutical ingredients but also into the reduction of side effects. In this chapter, a comprehensive overview about the manufacturing techniques and the most common polymers used for nanofibers production is discussed. The relation between the usefulness of these nanofibers with their composition, their size, and orientation is pointed out. Their medical applications on microbiology, namely the local administration of antibiotic drugs in infected areas, the development of wound dressing materials to improve the healing process and the possibility to raise or replace biological functions without organ transplantation by the use of artificial materials were analysed covering the developments accomplished over the last 10 years. It is noticed a lack of information about the formation of biofilms on the surface of nanofibrous scaffolds. Moreover, more studies must be done considering the nanoscale morphology and the type of polymer used, which seems to be crucial to prevent infections by microorganisms across medical applications.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abid S, Hussain T, Raza ZA, Nazir A (2019) Current applications of electrospun polymeric nanofibers in cancer therapy. Mater Sci Eng C Mater Biol Appl 97:966–977. https://doi.org/10.1016/j.msec.2018.12.105
Aldana AA, Abraham GA (2017) Current advances in electrospun gelatin-based scaffolds for tissue engineering applications. Int J Pharm 523(2):441–453. https://doi.org/10.1016/j.ijpharm.2016.09.044
Al-Enizi A, Zagho M, Elzatahry A (2018) Polymer-based electrospun nanofibers for biomedical applications. Nanomaterials 8(4):259. https://doi.org/10.3390/nano8040259
Alghoraibi I, Alomari S (2019) Handbook of nanofibers. Springer
Amariei G, Kokol V, Boltes K, Letón P, Rosal R (2018) Incorporation of antimicrobial peptides on electrospun nanofibres for biomedical applications. RSC Adv 8(49):28013–28023. https://doi.org/10.1039/C8RA03861A
Anitua E, Alonso R, Girbau C, Aguirre JJ, Muruzabal F, Orive G (2012) Antibacterial effect of plasma rich in growth factors (PRGF®-Endoret®) against Staphylococcus aureus and Staphylococcus epidermidis strains. Clin Exp Dermatol 37(6):652–657. https://doi.org/10.1111/j.1365-2230.2011.04303.x
Awasthi GP, Maharjan B, Shrestha S, Bhattarai DP, Yoon D, Park CH, Kim CS (2020) Synthesis, characterizations, and biocompatibility evaluation of polycaprolactone-MXene electrospun fibers. Colloids Surf A 586:124282. https://doi.org/10.1016/j.colsurfa.2019.124282
Azonano (2017) Classification of nanomaterials, the four main types of intentionally produced nanomaterials. https://www.azonano.com/article.aspx?ArticleID=1872
Bacakova L, Pajorova J, Tomkova M, Matejka R, Broz A, Stepanovska J et al (2020) Applications of nanocellulose/nanocarbon composites: focus on biotechnology and medicine. Nanomaterials 10(2):196. https://doi.org/10.3390/nano10020196
Barhoum A, Rasouli R, Yousefzadeh M, Rahier H, Bechelany M (2019) Handbook of nanofibers. Springer
Bertoncelj V, Pelipenko J, Kristl J, Jeras M, Cukjati M, Kocbek P (2014) Development and bioevaluation of nanofibers with blood-derived growth factors for dermal wound healing. Eur J Pharm Biopharm 88(1):64–74. https://doi.org/10.1016/j.ejpb.2014.06.001
Bongio M, van den Beucken JJJP, Leeuwenburgh SCG, Jansen JA (2010) Development of bone substitute materials: from ‘biocompatible’ to ‘instructive’. J Mater Chem 20(40):8747–8759. https://doi.org/10.1039/C0JM00795A
Burgess R (2012) Understanding nanomedicine an introductory textbook. Pan Stanford Publishing, Singapore
Charernsriwilaiwat N, Opanasopit P, Rojanarata T, Ngawhirunpat T (2012) Lysozyme-loaded, electrospun chitosan-based nanofiber mats for wound healing. Int J Pharm 427(2):379–384. https://doi.org/10.1016/j.ijpharm.2012.02.010
Chen S, Ge L, Gombart AF, Shuler FD, Carlson MA, Reilly DA, Xie J (2017a) Nanofiber-based sutures induce endogenous antimicrobial peptide. Nanomedicine 12(21):2597–2609. https://doi.org/10.2217/nnm-2017-0161
Chen Y, Yang W, Wang W, Zhang M, Li M (2017b) Bombyx mori silk fibroin scaffolds with Antheraea pernyi silk fibroin micro/nano fibers for promoting EA. hy926 cell proliferation. Materials (Basel) 10(10):1153. https://doi.org/10.3390/ma10101153
Chen Y, Qiu YY, Chen WBF, Wei QF (2020a) Electrospun thymol-loaded porous cellulose acetate fibers with potential biomedical applications. Mater Sci Eng C 109:110536. https://doi.org/10.1016/j.msec.2019.110536
Chen J, Zhang TH, Hua WK, Li PY, Wang XF (2020b) 3D porous poly(lactic acid)/regenerated cellulose composite scaffolds based on electrospun nanofibers for biomineralization. Colloids Surf A 585:124048. https://doi.org/10.1016/j.colsurfa.2019.124048
Cleeton C, Keirouz A, Chen XF, Radacsi N (2019) Electrospun nanofibers for drug delivery and biosensing. ACS Biomater Sci Eng 5(9):4183–4205. https://doi.org/10.1021/acsbiomaterials.9b00853
Cooley JF (1902) Apparatus for electrically dispersing fluids. Google Patents US692631A
De Cesare F, Di Mattia E, Zussman E, Macagnano A (2019) A study on the dependence of bacteria adhesion on the polymer nanofibre diameter. Environ Sci Nano 6(3):778–797. https://doi.org/10.1039/C8EN01237G
Desai K, Kit K, Li J, Zivanovic S (2008) Morphological and surface properties of electrospun chitosan nanofibers. Biomacromolecules 9(3):1000–1006. https://doi.org/10.1021/bm701017z
Doshi J, Reneker DH (1995) Electrospinning process and applications of electrospun fibers. J Electrost 35(2–3):151–160. https://doi.org/10.1016/0304-3886(95)00041-8
Eren Boncu T, Ozdemir N, Uskudar Guclu A (2020) Electrospinning of linezolid loaded PLGA nanofibers: effect of solvents on its spinnability, drug delivery, mechanical properties, and antibacterial activities. Drug Dev Ind Pharm 46(1):109–121. https://doi.org/10.1080/03639045.2019.1706550
Eriksen THB, Skovsen E, Fojan P (2013) Release of antimicrobial peptides from electrospun nanofibres as a drug delivery system. J Biomed Nanotechnol 9(3):492–498. https://doi.org/10.1166/jbn.2013.1553
Esmaeili E, Eslami-Arshaghi T, Hosseinzadeh S, Elahirad E, Jamalpoor Z, Hatamie S, Soleimani M (2020) The biomedical potential of cellulose acetate/polyurethane nanofibrous mats containing reduced graphene oxide/silver nanocomposites and curcumin: antimicrobial performance and cutaneous wound healing. Int J Biol Macromol 152:418–427. https://doi.org/10.1016/j.ijbiomac.2020.02.295
Fayemi OE, Ekennia AC, Katata-Seru L, Ebokaiwe AP, Ijomone OM, Onwudiwe DC, Ebenso EE (2018) Antimicrobial and wound healing properties of polyacrylonitrile-moringa extract nanofibers. Acs Omega 3(5):4791–4797. https://doi.org/10.1021/acsomega.7b01981
FDA (2012) FDA’s approach to regulation of nanotechnology products. https://www.fda.gov/science-research/nanotechnology-programs-fda/fdas-approach-regulation-nanotechnology-products
Feynman RP (1960) There’s plenty of room at the bottom. Eng Sci 23(5):22–36
Gao Y, Shao W, Qian W, He J, Zhou Y, Qi K et al (2018) Biomineralized poly (l-lactic-co-glycolic acid)-tussah silk fibroin nanofiber fabric with hierarchical architecture as a scaffold for bone tissue engineering. Mater Sci Eng C 84:195–207. https://doi.org/10.1016/j.msec.2017.11.047
Gao XZ, Han SY, Zhang RH, Liu GT, Wu J (2019) Progress in electrospun composite nanofibers: composition, performance and applications for tissue engineering. J Mater Chem B 7(45):7075–7089. https://doi.org/10.1039/c9tb01730e
Garcia-Orue I, Gainza G, Gutierrez FB, Aguirre JJ, Evora C, Pedraz JL et al (2017) Novel nanofibrous dressings containing rhEGF and Aloe vera for wound healing applications. Int J Pharm 523(2):556–566. https://doi.org/10.1016/j.ijpharm.2016.11.006
Ghosh PK, Murthy RS (2006) Microemulsions: a potential drug delivery system. Curr Drug Deliv 3(2):167–180. https://doi.org/10.2174/156720106776359168
Gnach A, Lipinski T, Bednarkiewicz A, Rybka J, Capobianco JA (2015) Upconverting nanoparticles: assessing the toxicity. Chem Soc Rev 44(6):1561–1584. https://doi.org/10.1039/c4cs00177j
Greiner A, Wendorff JH (2007) Electrospinning: a fascinating method for the preparation of ultrathin fibres. Angew Chem Int Ed 46(30):5670–5703. https://doi.org/10.1002/anie.200604646
Gubala V, Johnston LJ, Liu ZW, Krug H, Moore CJ, Ober CK et al (2018) Engineered nanomaterials and human health: part 1. Preparation, functionalization and characterization (IUPAC technical report). Pure Appl Chem 90(8):1283–1324. https://doi.org/10.1515/pac-2017-0101
Hardy A, Benford D, Halldorsson T, Jeger MJ, Knutsen HK, More S et al (2018) Guidance on risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain: part 1, human and animal health. EFSA J 16(7):5327. https://doi.org/10.2903/j.efsa.2018.5327
Homaeigohar S, Boccaccini AR (2020) Antibacterial biohybrid nanofibers for wound dressings. Acta Biomater 107:25–49. https://doi.org/10.1016/j.actbio.2020.02.022
Huang ZM, He CL, Yang A, Zhang Y, Han XJ, Yin J, Wu Q (2006) Encapsulating drugs in biodegradable ultrafine fibers through co-axial electrospinning. J Biomed Mater Res A 77(1):169–179. https://doi.org/10.1002/jbm.a.30564
Inamuddin, Ahamed MI, Prasad R (2021) Advanced antimicrobial materials and applications. Springer, Singapore. ISBN 978-981-15-7098-8. https://www.springer.com/gp/book/9789811570971
Jain KK (2019) The handbook of nanomedicine. Humana Press and Springer, Totowa, NJ
Kang MS, Kim J-H, Singh RK, Jang J-H, Kim H-W (2015) Therapeutic-designed electrospun bone scaffolds: mesoporous bioactive nanocarriers in hollow fiber composites to sequentially deliver dual growth factors. Acta Biomater 16:103–116. https://doi.org/10.1016/j.actbio.2014.12.028
Kegere J, Ouf A, Siam R, Mamdouh W (2019) Fabrication of poly(vinyl alcohol)/chitosan/bidens pilosa composite electrospun nanofibers with enhanced antibacterial activities. Acs Omega 4(5):8778–8785. https://doi.org/10.1021/acsomega.9b00204
Kenawy E-R, Bowlin GL, Mansfield K, Layman J, Simpson DG, Sanders EH, Wnek GE (2002) Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend. J Control Release 81(1):57–64. https://doi.org/10.1016/S0168-3659(02)00041-X
Khoshbakht S, Asghari-Sana F, Fathi-Azarbayjani A, Sharifi Y (2020) Fabrication and characterization of tretinoin-loaded nanofiber for topical skin delivery. Biomater Res 24:8. https://doi.org/10.1186/s40824-020-00186-3
Kim BJ, Kim S, Oh DX, Masic A, Cha HJ, Hwang DS (2015) Mussel-inspired adhesive protein-based electrospun nanofibers reinforced by Fe(iii)–DOPA complexation. J Mater Chem B 3(1):112–118. https://doi.org/10.1039/C4TB01496K
Kitto T, Bodart-Le Guen C, Rossetti N, Cicoira F (2019) 25 - processing and patterning of conducting polymers for flexible, stretchable, and biomedical electronics. In: Ostroverkhova O (ed) Handbook of organic materials for electronic and photonic devices, 2nd edn. Woodhead Publishing, pp 817–842
Kurtz IS, Schiffman JD (2018) Current and emerging approaches to engineer antibacterial and antifouling electrospun nanofibers. Materials (Basel) 11(7):1059. https://doi.org/10.3390/ma11071059
Laurencin CT, Ambrosio AMA, Borden MD, Cooper JA, J. (1999) Tissue engineering: orthopedic applications. Annu Rev Biomed Eng 1(1):19–46. https://doi.org/10.1146/annurev.bioeng.1.1.19
Lee SJ, Heo DN, Moon JH, Ko WK, Lee JB, Bae MS et al (2014) Electrospun chitosan nanofibers with controlled levels of silver nanoparticles. Preparation, characterization and antibacterial activity. Carbohydr Polym 111:530–537. https://doi.org/10.1016/j.carbpol.2014.04.026
Lee H, Lim S, Birajdar MS, Lee S-H, Park H (2016) Fabrication of FGF-2 immobilized electrospun gelatin nanofibers for tissue engineering. Int J Biol Macromol 93:1559–1566. https://doi.org/10.1016/j.ijbiomac.2016.07.041
Liu Z, Li S, Su L, Sun K, Wu X, Wu F et al (2015) Novel superhydrophilic poly(l-lactic acid-co-ε-caprolactone)/fibrinogen electrospun patch for rat abdominal wall reconstruction. J Biomater Appl 30(2):230–238. https://doi.org/10.1177/0885328215577732
Liu Y, Wang Q, Lu Y, Deng HB, Zhou X (2020) Synergistic enhancement of cytotoxicity against cancer cells by incorporation of rectorite into the paclitaxel immobilized cellulose acetate nanofibers. Int J Biol Macromol 152:672–680. https://doi.org/10.1016/j.ijbiomac.2020.02.184
Lu WJ, Sun JS, Jiang XY (2014) Recent advances in electrospinning technology and biomedical applications of electrospun fibers. J Mater Chem B 2(17):2369–2380. https://doi.org/10.1039/c3tb21478h
Lu Y, Shah KW, Xu JW (2017) Synthesis, morphologies and building applications of nanostructured polymers. Polymers 9(10):506. https://doi.org/10.3390/polym9100506
Machado R, da Costa A, Sencadas V, Garcia-Arévalo C, Costa CM, Padrão J et al (2013) Electrospun silk-elastin-like fibre mats for tissue engineering applications. Biomed Mater 8(6):065009. https://doi.org/10.1088/1748-6041/8/6/065009
Mamidi N, Zuniga AE, Villela-Castrejon J (2020) Engineering and evaluation of forcespun functionalized carbon nano-onions reinforced poly (epsilon-caprolactone) composite nanofibers for pH-responsive drug release. Mater Sci Eng C 112:110928. https://doi.org/10.1016/j.msec.2020.110928
Mira A, Sainz-Urruela C, Codina H, Jenkins SI, Rodriguez-Diaz JC, Mallavia R, Falco A (2020) Physico-chemically distinct nanomaterials synthesized from derivates of a poly(anhydride) diversify the spectrum of loadable antibiotics. Nanomaterials (Basel) 10(3):486. https://doi.org/10.3390/nano10030486
Mody N, Tekade RK, Mehra NK, Chopdey P, Jain NK (2014) Dendrimer, liposomes, carbon nanotubes and PLGA nanoparticles: one platform assessment of drug delivery potential. AAPS PharmSciTech 15(2):388–399. https://doi.org/10.1208/s12249-014-0073-3
Monaco JL, Lawrence WT (2003) Acute wound healing an overview. Clin Plast Surg 30:1), 1–1),12. https://doi.org/10.1016/s0094-1298(02)00070-6
Mottaghitalab F, Farokhi M, Shokrgozar MA, Atyabi F, Hosseinkhani H (2015) Silk fibroin nanoparticle as a novel drug delivery system. J Control Release 206:161–176. https://doi.org/10.1016/j.jconrel.2015.03.020
Nair LS, Laurencin CT (2007) Biodegradable polymers as biomaterials. Prog Polym Sci 32(8):762–798. https://doi.org/10.1016/j.progpolymsci.2007.05.017
Nejad MR, Yousefzadeh M, Solouk A (2020) Electrospun PET/PCL small diameter nanofibrous conduit for biomedical application. Mater Sci Eng C 110:110692. https://doi.org/10.1016/j.msec.2020.110692
O’Brien FJ (2011) Biomaterials & scaffolds for tissue engineering. Mater Today 14(3):88–95. https://doi.org/10.1016/S1369-7021(11)70058-X
Ojah N, Saikia D, Gogoi D, Baishya P, Ahmed GA, Ramteke A, Choudhury AJ (2019) Surface modification of core-shell silk/PVA nanofibers by oxygen dielectric barrier discharge plasma: studies of physico-chemical properties and drug release behavior. Appl Surf Sci 475:219–229. https://doi.org/10.1016/j.apsusc.2018.12.270
Park SH, Oh SG, Mun JY, Han SS (2006) Loading of gold nanoparticles inside the DPPC bilayers of liposome and their effects on membrane fluidities. Colloids Surf B 48(2):112–118. https://doi.org/10.1016/j.colsurfb.2006.01.006
Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MDP, Acosta-Torres LS et al (2018) Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol 16:71. https://doi.org/10.1186/s12951-018-0392-8
Peran M, Garcia MA, Lopez-Ruiz E, Jimenez G, Marchal JA (2013) How can nanotechnology help to repair the body? Advances in cardiac, skin, bone, cartilage and nerve tissue regeneration. Materials 6(4):1333–1359. https://doi.org/10.3390/ma6041333
Polini A, Yang F (2017) Physicochemical characterization of nanofiber composites. In: Nanofiber composites for biomedical application. Elsevier, pp 97–115
Prasad R, Pandey R, Varma A, Barman I (2017) Polymer based nanoparticles for drug delivery systems and cancer therapeutics. In: Kharkwal H, Janaswamy S (eds) Natural polymers for drug delivery. CAB International, London, pp 53–70
Rajabi M, Ali A, McConnell M, Cabral J (2020) Keratinous materials: structures and functions in biomedical applications. Mater Sci Eng C 110:110612. https://doi.org/10.1016/j.msec.2019.110612
Ramji K, Shah RN (2014) Electrospun soy protein nanofiber scaffolds for tissue regeneration. J Biomater Appl 29(3):411–422. https://doi.org/10.1177/0885328214530765
Reddy N, Yang Y (2008) Self-crosslinked gliadin fibers with high strength and water stability for potential medical applications. J Mater Sci Mater Med 19(5):2055–2061. https://doi.org/10.1007/s10856-007-3294-0
Reddy KVR, Yedery RD, Aranha C (2004) Antimicrobial peptides: premises and promises. Int J Antimicrob Agents 24(6):536–547. https://doi.org/10.1016/j.ijantimicag.2004.09.005
Rezaei Z, Mahmoudifard M (2019) Pivotal role of electrospun nanofibers in microfluidic diagnostic systems—a review. J Mater Chem B 7(30):4602–4619. https://doi.org/10.1039/c9tb00682f
Rosa AR, Steffens D, Santi B, Quintiliano K, Steffen N, Pilger DA, Pranke P (2017) Development of VEGF-loaded PLGA matrices in association with mesenchymal stem cells for tissue engineering. Braz J Med Biol Res 50(9):e5648. https://doi.org/10.1590/1414-431x20175648
Safdari M, Shakiba E, Kiaie SH, Fattahi A (2016) Preparation and characterization of Ceftazidime loaded electrospun silk fibroin/gelatin mat for wound dressing. Fibers Polym 17(5):744–750. https://doi.org/10.1007/s12221-016-5822-3
Sarhan WA, Azzazy HM (2017) Apitherapeutics and phage-loaded nanofibers as wound dressings with enhanced wound healing and antibacterial activity. Nanomedicine 12(17):2055–2067. https://doi.org/10.2217/nnm-2017-0151
SCCS (2020) The SCCS guidance on the safety assessment of nanomaterials in cosmetics comment. Regul Toxicol Pharmacol 112:104611. https://doi.org/10.1016/j.yrtph.2020.104611
Sebe I, Ostorhazi E, Fekete A, Kovacs KN, Zelko R, Kovalszky I et al (2016) Polyvinyl alcohol nanofiber formulation of the designer antimicrobial peptide APO sterilizes acinetobacter baumannii-infected skin wounds in mice. Amino Acids 48(1):203–211. https://doi.org/10.1007/s00726-015-2080-4
Sedghi R, Shaabani A, Mohammadi Z, Samadi FY, Isaei E (2017) Biocompatible electrospinning chitosan nanofibers: a novel delivery system with superior local cancer therapy. Carbohydr Polym 159:1–10. https://doi.org/10.1016/j.carbpol.2016.12.011
Selvaraj S, Thangam R, Fathima NN (2018) Electrospinning of casein nanofibers with silver nanoparticles for potential biomedical applications. Int J Biol Macromol 120:1674–1681. https://doi.org/10.1016/j.ijbiomac.2018.09.177
Shahi RG, Albuquerque MTP, Munchow EA, Blanchard SB, Gregory RL, Bottino MC (2017) Novel bioactive tetracycline-containing electrospun polymer fibers as a potential antibacterial dental implant coating. Odontology 105(3):354–363. https://doi.org/10.1007/s10266-016-0268-z
Shahini Shams Abadi M, Mirzaei E, Bazargani A, Gholipour A, Heidari H, Hadi N (2020) Antibacterial activity and mechanism of action of chitosan nanofibers against toxigenic Clostridioides (clostridium) difficile isolates. Ann Ig 32(1):72–80. https://doi.org/10.7416/ai.2020.2332
Shalumon KT, Anulekha KH, Nair SV, Nair SV, Chennazhi KP, Jayakumar R (2011) Sodium alginate/poly(vinyl alcohol)/nano ZnO composite nanofibers for antibacterial wound dressings. Int J Biol Macromol 49(3):247–254. https://doi.org/10.1016/j.ijbiomac.2011.04.005
Sharma J, Lizu M, Stewart M, Zygula K, Lu Y, Chauhan R et al (2015) Multifunctional nanofibers towards active biomedical therapeutics. Polymers 7(2):186–219. https://doi.org/10.3390/polym7020186
Shefa AA, Taz M, Hossain M, Kim YS, Lee SY, Lee BT (2019) Investigation of efficiency of a novel, zinc oxide loaded TEMPO-oxidized cellulose nanofiber based hemostat for topical bleeding. Int J Biol Macromol 126:786–795. https://doi.org/10.1016/j.ijbiomac.2018.12.079
Shin SH, Purevdorj O, Castano O, Planell JA, Kim HW (2012) A short review: recent advances in electrospinning for bone tissue regeneration. J Tissue Eng 3(1):2041731412443530. https://doi.org/10.1177/2041731412443530
Shoba E, Lakra R, Syamala Kiran M, Korrapati PS (2017) Fabrication of core–shell nanofibers for controlled delivery of bromelain and salvianolic acid B for skin regeneration in wound therapeutics. Biomed Mater 12(3):035005. https://doi.org/10.1088/1748-605x/aa6684
Ske (2020) Electrospinning system—needleless version. http://www.ske.it/index.php/product/electrospinning-system-needleless-electrospinning/
Song DW, Kim SH, Kim HH, Lee KH, Ki CS, Park YH (2016) Multi-biofunction of antimicrobial peptide-immobilized silk fibroin nanofiber membrane: implications for wound healing. Acta Biomater 39:146–155. https://doi.org/10.1016/j.actbio.2016.05.008
Song J, Klymov A, Shao J, Zhang Y, Ji W, Kolwijck E et al (2017) Electrospun nanofibrous silk fibroin membranes containing gelatin nanospheres for controlled delivery of biomolecules. Adv Healthc Mater 6(14):1700014. https://doi.org/10.1002/adhm.201700014
Tahmasebi A, Enderami SE, Saburi E, Islami M, Yaslianifard S, Mahabadi JA et al (2020) Micro-RNA-incorporated electrospun nanofibers improve osteogenic differentiation of human-induced pluripotent stem cells. J Biomed Mater Res A 108(2):377–386. https://doi.org/10.1002/jbm.a.36824
Tao FH, Cheng YX, Shi XW, Zheng HF, Du YM, Xiang W, Deng HB (2020) Applications of chitin and chitosan nanofibers in bone regenerative engineering. Carbohydr Polym 230:115658. https://doi.org/10.1016/j.carbpol.2019.115658
Thangadurai D, Sangeetha J, Prasad R (2020a) Nanotechnology for food, agriculture, and environment. Springer International Publishing, Cham. ISBN 978-3-030-31937-3. https://www.springer.com/gp/book/9783030319373
Thangadurai D, Sangeetha J, Prasad R (2020b) Functional bionanomaterials. Springer International Publishing, Cham. ISBN 978-3-030-41464-1. https://www.springer.com/gp/book/9783030414634
Tiwari SK, Tzezana R, Zussman E, Venkatraman SS (2010) Optimizing partition-controlled drug release from electrospun core–shell fibers. Int J Pharm 392(1):209–217. https://doi.org/10.1016/j.ijpharm.2010.03.021
Tsuji JS, Maynard AD, Howard PC, James JT, Lam CW, Warheit DB, Santamaria AB (2006) Research strategies for safety evaluation of nanomaterials, part IV: risk assessment of nanoparticles. Toxicol Sci 89(1):42–50. https://doi.org/10.1093/toxsci/kfi339
Tucker N, Stanger JJ, Staiger MP, Razzaq H, Hofman K (2012) The history of the science and technology of electrospinning from 1600 to 1995. J Eng Fibers Fabr 7:63–73. https://doi.org/10.1177/155892501200702S10
Uehara TM, Paino IMM, Santos FA, Scagion VP, Correa DS, Zucolotto V (2020) Fabrication of random and aligned electrospun nanofibers containing graphene oxide for skeletal muscle cells scaffold. Polym Adv Technol 31(6):1437–1443. https://doi.org/10.1002/pat.4874
Ulubayram K, Calamak S, Shahbazi R, Eroglu I (2015) Nanofibers based antibacterial drug design, delivery and applications. Curr Pharm Des 21(15):1930–1943. https://doi.org/10.2174/1381612821666150302151804
Valmikinathan CM, Defroda S, Yu X (2009) Polycaprolactone and bovine serum albumin based nanofibers for controlled release of nerve growth factor. Biomacromolecules 10(5):1084–1089. https://doi.org/10.1021/bm8012499
Vasita R, Katti DS (2006) Nanofibers and their applications in tissue engineering. Int J Nanomed 1(1):15–30. https://doi.org/10.2147/nano.2006.1.1.15
Venkataraman S, Hedrick JL, Ong ZY, Yang C, Ee PLR, Hammond PT, Yang YY (2011) The effects of polymeric nanostructure shape on drug delivery. Adv Drug Deliv Rev 63(14–15):1228–1246. https://doi.org/10.1016/j.addr.2011.06.016
Verreck G, Chun I, Peeters J, Rosenblatt J, Brewster ME (2003) Preparation and characterization of Nanofibers containing amorphous drug dispersions generated by electrostatic spinning. Pharm Res 20(5):810–817. https://doi.org/10.1023/A:1023450006281
Vert M, Doi Y, Hellwich KH, Hess M, Hodge P, Kubisa P et al (2012) Terminology for biorelated polymers and applications (IUPAC recommendations 2012). Pure Appl Chem 84(2):377–408. https://doi.org/10.1351/pac-rec-10-12-04
Wang J, Windbergs M (2017) Functional electrospun fibers for the treatment of human skin wounds. Eur J Pharm Biopharm 119:283–299. https://doi.org/10.1016/j.ejpb.2017.07.001
Wang Z-G, Wan L-S, Xu Z-K (2007) Surface engineerings of polyacrylonitrile-based asymmetric membranes towards biomedical applications: an overview. J Membr Sci 304(1):8–23. https://doi.org/10.1016/j.memsci.2007.05.012
Wang S-D, Ma Q, Wang K, Chen H-W (2018) Improving antibacterial activity and biocompatibility of bioinspired electrospinning silk fibroin nanofibers modified by graphene oxide. Acs Omega 3(1):406–413. https://doi.org/10.1021/acsomega.7b01210
Whitehead TJ, Avila COC, Sundararaghavan HG (2018) Combining growth factor releasing microspheres within aligned nanofibers enhances neurite outgrowth. J Biomed Mater Res A 106(1):17–25. https://doi.org/10.1002/jbm.a.36204
Won JJ, Nirmala R, Navamathavan R, Kim HY (2012) Electrospun core–shell nanofibers from homogeneous solution of poly(vinyl alcohol)/bovine serum albumin. Int J Biol Macromol 50(5):1292–1298. https://doi.org/10.1016/j.ijbiomac.2012.04.007
Xu R, Zhang Z, Toftdal MS, Møller AC, Dagnaes-Hansen F, Dong M et al (2019) Synchronous delivery of hydroxyapatite and connective tissue growth factor derived osteoinductive peptide enhanced osteogenesis. J Control Release 301:129–139. https://doi.org/10.1016/j.jconrel.2019.02.037
Xue JJ, Wu T, Dai YQ, Xia YN (2019) Electrospinning and electrospun nanofibers: methods, materials, and applications. Chem Rev 119(8):5298–5415. https://doi.org/10.1021/acs.chemrev.8b00593
Yan EY, Jiang JY, Yang XY, Fan LQ, Wang YW, An QL et al (2020) pH-sensitive core-shell electrospun nanofibers based on polyvinyl alcohol/polycaprolactone as a potential drug delivery system for the chemotherapy against cervical cancer. J Drug Deliv Sci Technol 55:101455. https://doi.org/10.1016/j.jddst.2019.101455
Yang X, Yang J, Wang L, Ran B, Jia Y, Zhang L et al (2017) Pharmaceutical intermediate-modified gold nanoparticles: against multidrug-resistant Bacteria and wound-healing application via an electrospun scaffold. ACS Nano 11(6):5737–5745. https://doi.org/10.1021/acsnano.7b01240
Yang YN, Lu KY, Wang P, Ho YC, Tsai ML, Mi FL (2020) Development of bacterial cellulose/chitin multi-nanofibers based smart films containing natural active microspheres and nanoparticles formed in situ. Carbohydr Polym 228:115370. https://doi.org/10.1016/j.carbpol.2019.115370
Yao C-H, Yeh J-Y, Chen Y-S, Li M-H, Huang C-H (2017) Wound-healing effect of electrospun gelatin nanofibres containing centella asiatica extract in a rat model. J Tissue Eng Regen Med 11(3):905–915. https://doi.org/10.1002/term.1992
Ye P, Wei S, Luo C, Wang Q, Li A, Wei F (2020) Long-term effect against methicillin-resistant Staphylococcus aureus of emodin released from coaxial electrospinning nanofiber membranes with a biphasic profile. Biomol Ther 10(3):362. https://doi.org/10.3390/biom10030362
Yildiz A, Kara AA, Acarturk F (2020) Peptide-protein based nanofibers in pharmaceutical and biomedical applications. Int J Biol Macromol 148:1084–1097. https://doi.org/10.1016/j.ijbiomac.2019.12.275
Yoshimoto H, Shin YM, Terai H, Vacanti JP (2003) A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials 24(12):2077–2082. https://doi.org/10.1016/S0142-9612(02)00635-X
Yu C-C, Chang J-J, Lee Y-H, Lin Y-C, Wu M-H, Yang M-C, Chien C-T (2013) Electrospun scaffolds composing of alginate, chitosan, collagen and hydroxyapatite for applying in bone tissue engineering. Mater Lett 93:133–136. https://doi.org/10.1016/j.matlet.2012.11.040
Yuan MQ, Dai FF, Li D, Fan YQ, Xiang W, Tao FH et al (2020) Lysozyme/collagen multilayers layer-by-layer deposited nanofibers with enhanced biocompatibility and antibacterial activity. Mater Sci Eng C 112:110868. https://doi.org/10.1016/j.msec.2020.110868
Zhang Y, Cui L, Che X, Zhang H, Shi N, Li C et al (2015) Zein-based films and their usage for controlled delivery: origin, classes and current landscape. J Control Release 206:206–219. https://doi.org/10.1016/j.jconrel.2015.03.030
Zigdon-Giladi H, Khutaba A, Elimelech R, Machtei EE, Srouji S (2017) VEGF release from a polymeric nanofiber scaffold for improved angiogenesis. J Biomed Mater Res A 105(10):2712–2721. https://doi.org/10.1002/jbm.a.36127
Zupancic S, Rijavec T, Lapanje A, Petelin M, Kristl J, Kocbek P (2018) Nanofibers with incorporated autochthonous bacteria as potential probiotics for local treatment of periodontal disease. Biomacromolecules 19(11):4299–4306. https://doi.org/10.1021/acs.biomac.8b01181
Acknowledgments
This work was supported by the National Funds through FCT/MCTES—Portuguese Foundation for Science and Technology within the scope of the project UIDB/50006/2020. Renato Gil thanks FCT (Fundação para a Ciência e Tecnologia) and ESF (European Social Fund) through POCH (Programa Operacional Capital Humano) for his PhD grant SFRH/BD/131504/2017.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Gil, R.L., Amorim, C.G., Rodríguez-Díaz, J.M., Araújo, A.N., Montenegro, M.C.B.S.M. (2021). Nanofibers in Medical Microbiology. In: Maddela, N.R., Chakraborty, S., Prasad, R. (eds) Nanotechnology for Advances in Medical Microbiology. Environmental and Microbial Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-15-9916-3_4
Download citation
DOI: https://doi.org/10.1007/978-981-15-9916-3_4
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-9915-6
Online ISBN: 978-981-15-9916-3
eBook Packages: Earth and Environmental ScienceEarth and Environmental Science (R0)