Abstract
With the evolution of technology and radiotracers, PET-CT has become an important imaging modality to evaluate the infection and inflammatory process. FDG is the most commonly used radiotracer; however, newer radiotracers are also under preclinical research.
The biggest advantage is noninvasive whole-body evaluation in a single scan. Common radiotracers used for different pathologies like FDG, 18F NaF, Gallium 68 for various applications. Various pathologies involving muscles, nerves, skeletons, and joints can be evaluated. Recently PET-MR is going to be a very crucial imaging modality for final details of cartilage, synovium, muscles, and neurovascular bundles.
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References
Osman DR. Diagnosis and management of musculoskeletal infection. In: Fitzgerald RH, Haufer H, Malkani RL, editors. Orthopedics. St. Louis: Mosby; 2002. p. 695–707.
Love C, Tomas MB, Tronco GG, et al. Imaging infection and inflammation with 18F-FDG-PET. Radiographics. 2005;25:1357–68.
Strobel K, KDM S. PET/CT in musculoskeletal infection. Semin Musculoskelet Radiol. 2007;11:353–64.
Kalicke T, Schmitz A, Risse JH, et al. Fluorine-18 fluorodeoxyglucose PET in infectious bone diseases: results of histologically confirmed cases. Eur J Nucl Med Mol Imaging. 2000;27:524–8.
Apolo AB, Lindenberg L, Shih JH, Mena E, Kim JW, Park JC, et al. Prospective study evaluating Na18F PET/CT in predicting clinical outcomes and survival in advanced prostate cancer. J Nucl Med. 2016;57(6):886–92.
Yilmaz S, Aliyev A, Ekmekcioglu O, Ozhan M, Uslu L, Vatankulu B, Sager S, Halaç M, Sönmezoğlu K. Comparison of FDG and FDG-labeled leukocytes PET/CT in diagnosis of infection. Nuklearmedizin. 2015;54:262–71.
Salomaki SP, Kemppainen J, Hohenthal U, et al. Head-to-head comparison of (68)Ga-citrate and (18)F-FDG PET/CT for detection of infectious foci in patients with Staphylococcus aureus Bacteraemia. Contrast Media Mol Imaging. 2017;2017:3179607.
Makis W, Stern J. Chronic vascular graft infection with fistula to bone causing vertebral osteomyelitis, imaged with F-18 FDG PET/CT. Clin Nucl Med. 2010;35(10):794–6.
Guhlmann A, Brecht-Krauss D, Suger G, et al. Fluorine-18-FDG PET and technetium-99 mantigranulocyte antibody scintigraphy in chronic osteomyelitis. J Nucl Med. 1998;39:2145–52.
Zhuang H, Duarte PS, Pourdehand M, et al. Exclusion of chronic osteomyelitis with F-18 fluorodeoxyglucose positron emission tomographic imaging. Clin Nucl Med. 2000;25:281–4.
Meller J, Koster G, Liersch T, et al. Chronic bacterial osteomyelitis: prospective comparison of F-18-FDG imaging with a dual-head coincidence camera and In-111-labelled autologousleucocyte scintigraphy. Eur J Nucl Med Mol Imaging. 2002;29:53–60.
Nakamura H, Masuko K, Yudoh K, et al. Positron emission tomography with 18F-FDG in osteoarthritic knee. Osteoarthr Cartil. 2007;15(6):673–81.
Warmann SW, Dittmann H. Guido Seitz follow-up of acute osteomyelitis in children: the possible role of PET/CT in selected cases. J Pediatr Surg. 2011;46(8):1550–6.
Schmitz A, Risse JH, Grunwald F, et al. Fluorine-18 fluorodeoxyglucose positron emission tomography findings in spondylodiscitis: preliminary results. Eur Spine J. 2001;10:534–9.
Nawaz A, Torigian DA, Siegelman ES, et al. Diagnostic performance of FDG-PET, MRI, and plain film radiography(PFR) forth diagnosis of osteomyelitis in the diabetic foot. Mol Imaging Biol. 2010;12:335–42.
Hopfner S, Krolak C, Kessler S, et al. Pre-operative imaging of Charcot neuroarthropathy in diabetic patients: comparison of ring PET, hybrid PET, and magnetic resonance imaging. Foot Ankle Int. 2004;25:890–5.
Lawrence E., et al. Periprosthetic joint infections: clinical and bench research. Sci World J. 2013. 549091, 17 p.
Basu S, Kwee TC, Hess S. FDG-PET/CT imaging of infected bones and prosthetic joints. Curr Mol Imaging. 2014;3(3):225–9.
Suto T, Okamura K, Yonemoto Y, Okura C, Tsushima Y, Takagishi K. Prediction of large joint destruction in patients with rheumatoid arthritis using 18F-FDG PET/CT and disease activity score. Medicine (Baltimore). 2016;95:e2841.
Alhilali L, Reynolds AR, Fakhran S. Osteoradionecrosis after radiation therapy for head and neck cancer: differentiation from recurrent disease with CT and PET/CT imaging. AJNR Am J Neuroradiol. 2014;35:1405–11. https://doi.org/10.3174/ajnr.A3879.
Katzel JA, Heiba SI. PET/CT F-18 FDG scan accurately identifies osteoporotic fractures in a patient with known metastatic colorectal cancer. Clin Nucl Med. 2005;30(10):651–4.
Loffler C, Hoffend J, Benck U, Kramer BK, Bergner R. The value of ultrasound in diagnosing extracranial large-vessel vasculitis compared to FDG-PET/CT: a retrospective study. Clin Rheumatol. 2017;36:2079.
Shon IH, Fogelman I. F-18 FDG positron emission tomography and benign fractures. Clin Nucl Med. 2003;28(3):171–5.
Jadvar H, Desai B, Conti PS. Sodium 18 F-fluoride PET/CT of bone, joint, and other disorders. Semin Nucl Med. 2015;1:58–65. https://doi.org/10.1053/j.semnuclmed.2014.07.008.
Yamada S, Kubota K, Kubota R, Ido T, Tamahashi N. High accumulation of fluorine-18-fluorodeoxyglucose in turpentine-induced inflammatory tissue. J Nucl Med. 1995;36:1301–6.
Stumpe KD, Notzli HP, Zanetti M, et al. FDG PET for differentiation of infection and aseptic loosening into total hip replacements: comparison with conventional radiography and three-phase bone scintigraphy. Radiology. 2004;231:333–41.
Rheumatoid arthritis. The intense FDG accumulation in both hip joints can be noted. As with single photon emitting tracers, it is not likely that FDG plays a significant role in the diagnosis of the septic joint. FDG-PET in musculoskeletal infections 375 associated infections with FDG PET in patients with trauma: correlation with microbiologic results. Radiology. 2003;226:391–8.
Beckers C, Ribbens C, Andre B, Marcelis S, Kaye O, Mathy L, et al. Assessment of disease activity in rheumatoid arthritis with (18)F-FDG PET. J Nucl Med. 2004;45:956–64.
Mehta NN, Yu YD, Saboury B. Systemic and vascular inflammation in patients with moderate to severe psoriasis as measured by [18F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT): a pilot study. Arch Dermatol. 2011;147(9):1031–9.
Kamekura S, Hoshi K, Nakamura K, et al. Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthr Cartil. 2005;13(7):632–41.
Fischer DR. Musculoskeletal imaging using fluoride PET. Semin Nucl Med. 2013;43:427–33.
Even-Sapir E, Mishani E, Flusser G, Metser U. 18F-fluoride positron emission tomography and positron emission tomography/computed tomography. Semin Nucl Med. 2007;37:462–9.
Wong KK, Piert M. Dynamic bone imaging with 99mTc-labeled diphosphonates and 18FNaF: mechanisms and applications. J Nucl Med. 2013;54:590–9.
Pipitone N, Versari A, Zuccoli G, et al. 18F-fluorodeoxyglucose positron emission tomography for the assessment of myositis: a case series. Clin Exp Rheumatol. 2012;30:570–3.
hrapko BE, Chrapko M, Nocun A, Stefaniak B, Zubilewicz T, Drop A. Role of 18F-FDG PET/CT in the diagnosis of inflammatory and infectious vascular disease. Nucl Med Rev Cent East Eur. 2016;19:28–36. https://doi.org/10.5603/NMR.2016.0006.
Even-Sapir E, Metser U, Mishani E, Lievshitz G, Lerman H, Leibovitch I. The detection of bone metastases in patients with high-risk prostate cancer: 99mTc-MDP planar bone scintigraphy, single- and multi-field-of-view SPECT, 18F-fluoride PET, and 18F-fluoride PET/CT. J Nucl Med. 2006;47(2):287–97.
Cheng G, Chamroonrat W, Bing Z, et al. Elevated FDG activity in the spinal cord and the sciatic nerves due to neuropathy. Clin Nucl Med. 2009;34(12):950–1.
Kuyumcu S, Özkan ZG, Sanli Y, et al. Physiological and tumoral uptake of (68) Ga-DOTATATE: standardized uptake values and challenges in interpretation. Ann Nucl Med. 2013;27:538–45. https://doi.org/10.1007/s12149-013-0718-4.
Pomykala KL, Czernin J, Tristan R. Grogan total-body 68 Ga-PSMA-11 PET/CT for bone metastasis detection in prostate cancer patients: potential impact on bone scan guidelines. J Nucl Med. 2020;61(3):405–11.
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Shaikh, S. (2021). PET-CT in Musculoskeletal Infection and Inflammation. In: PET-CT in Infection and Inflammation. Springer, Singapore. https://doi.org/10.1007/978-981-15-9801-2_15
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DOI: https://doi.org/10.1007/978-981-15-9801-2_15
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