Abstract
Cancer is a multifactorial disease characterized by an uncontrolled growth of cells that can invade other tissues causing metastasis. Its incidence is increasing at an alarming rate worldwide, and is the second leading cause of death in the world, being considered a public health problem. Several factors like genetics, hormonal, radiation, viral, chemicals, obesity, and oxidative stress can all contribute to the development of cancer. Furthermore, studies have demonstrated that oxidative stress is an important factor for cancer progression and therapy. Oxidative stress is a state wherein high levels of reactive oxygen species (ROS) and free radicals are produced, and is characterized by an imbalance between antioxidant defense and the levels of prooxidant agents produced. ROS can contribute to carcinogenesis since they can stimulate cancer initiation promoting DNA mutations, damage to the cells, and activate pro-oncogenic signaling pathways. On the other hand, high levels of ROS can contribute to cancer cell death, promoting apoptosis and necrosis. β-Glucans, such as the (1 → 3)-β-D-glucans, have been described as effective in treating dyslipidemia, diabetes, cardiovascular-related diseases, and cancer. Studies have demonstrated that β-glucans present direct and indirect antitumoral effects that can be mediated by the action of an antioxidant or prooxidant. In this chapter, we provide an overview of the relationship between cancer, oxidative stress, and β-glucans, and discuss the effects of β-glucans on conditions of cancer and oxidative stress.
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Queiroz, E.A.I.F., Alegranci, P., Barbosa-Dekker, A.M., Dekker, R.F.H. (2021). Roles of β-Glucans in Oxidative Stress and Cancer. In: Chakraborti, S., Ray, B.K., Roychowdhury, S. (eds) Handbook of Oxidative Stress and Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-15-4501-6_3-1
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DOI: https://doi.org/10.1007/978-981-15-4501-6_3-1
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Roles of β-Glucans in Oxidative Stress and Cancer- Published:
- 04 August 2021
DOI: https://doi.org/10.1007/978-981-15-4501-6_3-2
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Roles of β-Glucans in Oxidative Stress and Cancer- Published:
- 13 February 2021
DOI: https://doi.org/10.1007/978-981-15-4501-6_3-1