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In Vivo Self-Assembly of Polypeptide-Based Nanomaterials

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Handbook of Macrocyclic Supramolecular Assembly

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Abstract

The highly ordered peptide nanostructures, such as nanotube, nanofibril, nanoparticle, nanowire, etc., are showing great application potential in bioimaging, cancer therapy, tissue engineering, antibacterial, and regenerative medicine field. The “in vivo self-assembly” is a strategy which has been put forward utilizing in vivo microenvironment response linker to control the peptide nanostructure. In this chapter, we firstly provided a short description of functional peptides and driving forces for self-assembly, followed by introduction of the principle and methods of “in vivo self-assembly strategy” mainly based on our published papers. After listing some typical self-assembled peptides, we focused on the discussion of “in vivo self-assembly strategy” triggered by pH, enzyme, temperature, ligand-receptor interaction, and redox reaction response with specific articles as example. The polymer-peptide conjugates (PPCs) self-assembly in vivo also was discussed. By providing a snapshot for chemists, engineers, and medical scientists, we hope that this chapter will contribute to insights and developments of multidisciplinary research on “in vivo self-assembly strategy” for a wide range of applications in different fields. Finally, we offer our perspective and outlook on this fast-growing strategy in supramolecular chemistry, nanobiomaterials, biology, and biomedicine.

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Acknowledgments

This work was supported by the National Science Fund for Distinguished Young Scholars (51725302).

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Authors and Affiliations

  1. CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing, China

    Man-Di Wang & Hao Wang

  2. University of Chinese Academy of Sciences (UCAS), Beijing, China

    Man-Di Wang & Hao Wang

  3. Beijing Academy, Beijing, China

    Yan-Qing Huang

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  1. Man-Di Wang
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  2. Yan-Qing Huang
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  3. Hao Wang
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Correspondence to Hao Wang .

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Editors and Affiliations

  1. College of Chemistry, Nankai University College of Chemistry, Tianjin, Tianjin, China

    Yu Liu

  2. College of Chemistry, Nankai University College of Chemistry, Tianjin, Tianjin, China

    Yong Chen

  3. College of Chemistry, Nankai University College of Chemistry, Tianjin, Tianjin, China

    Heng-Yi Zhang

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Wang, MD., Huang, YQ., Wang, H. (2019). In Vivo Self-Assembly of Polypeptide-Based Nanomaterials. In: Liu, Y., Chen, Y., Zhang, HY. (eds) Handbook of Macrocyclic Supramolecular Assembly . Springer, Singapore. https://doi.org/10.1007/978-981-13-1744-6_42-1

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