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The Significance of Single-Cell Biomedicine in Stem Cells

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Single Cell Biomedicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1068))

Abstract

Clinical application of stem cells (SCs) progresses significantly in the treatment of a large number of diseases, e.g. leukemia, respiratory diseases, kidney disease, cerebral palsy, autism, or autoimmune diseases. Of those, the population, biological phenotypes, and functions of individual SCs are mainly concerned, due to the lack of cell separation and purification processes. The single-cell technology, including microfluidic technology and single-cell genome amplification technology, is widely used to study SCs and gains some recognitions. The present review will address the importance of single-cell technologies in the recognition and heterogeneity of SCs and highlight the significance of current single-cell approaches in the understanding of SC phenotypes. We also discuss the values of single-cell studies to overcome the bottleneck in explore of biological mechanisms and reveal the therapeutic potentials of SCs in diseases, especially tumor-related diseases, as new diagnostic and therapeutic strategies

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Author information

Author notes

  1. Authors Weishan Zhuge and Furong Yan have equally contributed to this chapter as the first author.

Authors and Affiliations

  1. Zhongshan Hospital Institute of Clinical Science, Fudan University Shanghai Medical School, Shanghai, China

    Weishan Zhuge & Xiangdong Wang

  2. Department of Respiratory Pulmonary and Critical Care Medicine, The Second Hospital of Fujian Medical University, Quanzhou, Fujian Province, China

    Furong Yan

  3. The First Hospital of Jinzhou Medical University, JinZhou, Liaoning Province, China

    Zhitu Zhu

Authors
  1. Weishan Zhuge
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  2. Furong Yan
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  3. Zhitu Zhu
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  4. Xiangdong Wang
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Corresponding author

Correspondence to Xiangdong Wang .

Editor information

Editors and Affiliations

  1. Henan Provincial People’s Hospital, Zhengzhou, Henan, China

    Jianqin Gu

  2. Shanghai Institute of Clinical Bioinformatics, Zhongshan Hospital, Fudan University, Shanghai, China

    Xiangdong Wang

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© 2018 Springer Nature Singapore Pte Ltd.

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Zhuge, W., Yan, F., Zhu, Z., Wang, X. (2018). The Significance of Single-Cell Biomedicine in Stem Cells. In: Gu, J., Wang, X. (eds) Single Cell Biomedicine. Advances in Experimental Medicine and Biology, vol 1068. Springer, Singapore. https://doi.org/10.1007/978-981-13-0502-3_16

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