Abstract
In this study, we synthesized Galactose-Taurine sodium salt (G-T) as a functional food ingredient to enhance biological activities of taurine. Also, anti-inflammatory effects of G-T were investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. G-T found to reduce the generations of the LPS-stimulated nitric oxide (NO) and prostaglandin E2 (PGE2) via down-regulating the expression levels of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2). Also, G-T reduced the secretion of inflammatory cytokines including interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF-α) in LPS-treated RAW 264.7 cells. Finally, we identified that G-T inhibits the activation of nuclear factor-κB (NF-κB) and the phosphorylation of inhibitor κB (IκB)-α. From these results, this study first suggests that G-T could be considered as an effective anti-inflammatory agent.
$N. Kang and K.J. Chang are equally contributed to this study.
§S.H. Cheong and G. Ahn are equally contributed to this study.
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Abbreviations
- COX-2:
-
Cyclooxygenase-2
- Gal-Tau:
-
Galactose-Taurine sodium salt
- IκB-α:
-
Inhibitor κB-α
- IL-1β:
-
Interleukin-1β
- LPS:
-
Lipopolysaccharide
- NF-κB:
-
Nuclear factor-κB
- NO:
-
Nitric oxide
- iNOS:
-
Inducible NO synthase
- PGE2 :
-
Prostaglandin E2
- TNF-α:
-
Tumor necrosis factor-α
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Kang, N. et al. (2017). Anti-inflammatory Effects of Galactose-Taurine Sodium Salt in LPS-Activated RAW 264.7 Cells. In: Lee, DH., Schaffer, S.W., Park, E., Kim, H.W. (eds) Taurine 10. Advances in Experimental Medicine and Biology, vol 975. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1079-2_75
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