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Biosensing Instrumentation

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Nano-Structures for Optics and Photonics

Abstract

Functionalized nanoparticles revolutionized the sensing and imaging of biological samples. A particularly spectacular example was recently achieved with harmonic nanoparticles (HNPs), which allow coherent emission at harmonics of the fundamental wavelength over the whole VIS-NIR spectral range. Deep imaging, nanoscale in situ spatio-temporal focus characterization, on-line monitoring of stem cell differentiation and cancer theranostics are demonstrated. A further ground-breaking coherent approach is based on coherent control of endogenous biomolecules, which provides chemical selectivity at the protein level even “label-free”. State of the art and perspectives related to these new biosensing developments are presented

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Acknowledgements

The authors gratefully acknowledge the collaborators at the Universities of Geneva and Lyon, in particular L. Bonacina, F. Courvoisier, L. Guyon, V. Boutou, E. Salmon, J. Yu, G. Mejean, J. Kasparian, C. Kasparian, A. Rondi, S. Afonina, J. Extermann, P. Bejot, S. Weber, D. Kiselev, and M. Moret, as well as H. Rabitz and his group at Princeton, particularly M. Roth and J. Roslund.

We also acknowledge the financial support of the Swiss National Science Foundation (contracts No. 2000021-111688 and No. 200020-124689), the Swiss NCCR MUST, and European FP7 project NAMDIATREAM (NMP-2009-4.0-3-246479).

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Authors and Affiliations

  1. GAP-Biophotonics, University of Geneva, 22 chemin de Pinchat, 1211, Geneva 4, Switzerland

    Jean-Pierre Wolf

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  1. Jean-Pierre Wolf
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Correspondence to Jean-Pierre Wolf .

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Editors and Affiliations

  1. Department of Physics, Boston College, Chestnut Hill, Massachusetts, USA

    Baldassare Di Bartolo

  2. Department of Physics and Astronomy, Wheaton College, Norton, Massachusetts, USA

    John Collins

  3. Department of Physics, Boston College, Chestnut Hill, USA

    Luciano Silvestri

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Wolf, JP. (2015). Biosensing Instrumentation. In: Di Bartolo, B., Collins, J., Silvestri, L. (eds) Nano-Structures for Optics and Photonics. NATO Science for Peace and Security Series B: Physics and Biophysics. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9133-5_4

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