Abstract
The fungi represent a diverse assembly of heterotrophic eukaryotes. In principal, they can be divided into two groups, the yeasts and the mycelial (filamentous) fungi. In yeasts, a single cell predominantly represents the individuum. In contrast, the vegetation body of mycelial fungi is represented by the so-called mycelium, a thallus consisting of a network of long filamentous “cells,” termed hyphae. Mycelial growth proceeds via the elongation of the peripheral hyphae [1]. From time to time, these hyphae branch at their tips. If two independent mycelia come into close contact they may fuse by hyphal anastomoses giving rise to the formation of a heterokaryon, a mycelium containing the nuclei of the two fusion partners. This process is genetically controlled [2].
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References
Bartnicki-Garcia S (2002). Hyphal tip growth: outstanding questions. In: Osiewacz HD, ed. Molecular Biology of Fungal Development. New York, Basel: Marcel Dekker, pp. 29–58.
Glass NL, Saupe SJ (2002). Vegetative incompatibilityin filamentous ascomycetes. In: Osiewacz HD, ed. Molecular Biology of Fungal Development. New York, Basel: Marcel Dekker, pp. 109–32.
Mosch H-U (2002). Pseudohyphal growth in yeast. In: Osiewacz HD, ed. Molecular Biology of Fungal Development. New York, Basel: Marcel Dekker, pp. 1–27.
Smith ML, Bruhn JN and Anderson JB (1992). The fungus Armillaria bulbosa is amongst the largest and oldest living organisms. Nature 356: 428–431.
Barton AA (1950). Some aspects of cell division in Saccharomyces cerevisiae. J Gen Microbiol. 4: 84–87.
Mortimer RK, Johnston JR (1959). Life span of individual yeast cells. Nature 183: 1751–1752.
Marcou D (1961). Notion de longevite et nature cytoplasmatique du determinant de senescence chez quelques champignons. Ann Sci Nat Bot. 653–764.
Caten CE, Handley L (1978). Vegetative death syndrome in Aspergillus glaucus. Bull Br Mycol Soc. 12: 114.
Handley L, Caten CE (1973). Vegetative death: a mitochondrial mutation in Aspergillus amstelodami. Heredity 31: 136.
Lazarus CM, Earl AJ, Turner G, Kuntzel H (1980). Amplification of a mitochondrial DNA sequence in the cytoplasmically inherited “ragged’’ mutant of Aspergillus amstelodami. Eur JBiochem. 106: 633–41.
Lazarus CM, Kuntzel H (1981). Anatomy of amplified mitochondrial DNA in “ragged’’ mutants of Aspergillus amstelodami: excision points within genes and a common 215 bp segment containing a possible origin of amplification. Curr Genet. 4: 99–107.
Jinks JL (1956). Naturally occurring cytoplasmic changes changes in fungi. CR Trav Lab Carlsberg Ser Pysiol. 26: 183–203.
Lindberg GD (1959). A transmissible disease of Helminthosporium victoriae. Phytopathology 49: 29–52.
Bertrand H, Collins RA, Stohl LL, Goewert RR, Lambowitz AM (1980). Deletion mutants of Neurospora crassa mitochondrial DNA and their relationship to the “stop-start’’ growth phenotype. Proc Natl Acad Sci USA 77: 6032–6036.
de Vries H, de Jonge JC, van’t Sant S, Agsteribbe E, Arnberg A (1981). A “stopper’’ mutant of Neurospora crassa containing two populations of aberant mitochondrial DNA. Curr Genet. 3: 205–211.
Bertrand H, Chan BS, Griffiths AJ (1985). Insertion of a foreign nucleotide sequence into mitochondrial DNA causes senescence in Neurospora intermedia. Cell, 41: 877–884.
Akins RA, Kelley RL, Lambowitz AM (1986). Mitochondrial plasmids of Neurospora: integration into mitochondrial DNA and evidence for reverse transcription in mitochondria. Cell 47: 505–516.
de Vries H, Alzner-DeWeerd B, Breitenberger CA, Chang DD, de Jonge JC, RajBhandary UL (1986). The E35 stopper mutant of Neurospora crassa: precise localization of deletion endpoints in mitochondrial DNA and evidence that the deleted DNA codes for a subunit of NADH dehydrogenase. EMBO J. 5: 779–785.
Bertrand H, Wu Q, Seidel-Rogol BL (1993). Hyperactive recombination in the mitochondrial DNA of the natural death nuclear mutant of Neurospora crassa. Mol Cell Biol. 13: 6778–6788.
Rieck A, Griffiths AJ, Bertrand H (1982). Mitochondrial variants of Neurospora intermedia from nature. Can J Genet Cytol. 24: 741–759.
Griffiths AJF, Bertrand H (1984). Unstable cytoplasm in Hawaiian strains of Neurospora intermedia. Curr Genet. 8: 387–98.
Griffiths AJ, Yang X (1995). Recombination between heterologous linear and circular mitochondrial plasmids in the fungus Neurospora. Mol Gen Genet. 249: 25–36.
Bertrand H, Griffiths AJ, Court DA, Cheng CK (1986). An extrachromosomal plasmid is the etiological precursor of kalDNA insertion sequences in the mitochondrial chromosome of senescent Neurospora. Cell 47: 829–837.
Chevaugeon J, Digbeu S (1960). Un second facteur cytoplasmique infectant chez le Pestalozzia annulata. CR Acad Sci. 251: 3043–3061.
Rizet G (1953). Sur l’impossibilite d’obtenir la multiplication vegetative initerrompuet illimite de l’ascomycete Podospora anserina. CR Acad Sci Paris 237: 838–855.
Rizet G (1953). Sur la longevite des phenomen des souches de Podospora anserina. CR Acad Sci Paris 237: 1106–1109.
Bockelmann B, Esser K l1986). Plasmids of mitochondrial origin in senescent mycelia of Podospora curvicolla. Curr Genet. 10: 803–810.
Gagny B, Rossignol M, Silar P (1997). Cloning, sequencing, and transgenic expression of Podospora curvicolla and Sordaria macrospora eEF1A genes: relationship between cytosolic translation and longevityin filamentous fungi. Fungal Genet Biol. 22: 191–198.
Esser K, Tudzynski P l1980). Senescence in fungi. In: Thimann KV, ed. Senescence in Plants. Boca Raton: CRC Press, pp. 67–83.
Esser K, Kuck U, Lang-Hinrichs C, et al. l1986). Plasmids of Eukaryotes. Fundamentalsand Applications. Heidelberg, New York, Tokyo: Springer
Osiewacz HD (1990). Molecular analysis of aging processes in fungi. Mutat Res. 237: 1–8.
Griffiths AJ (1992). Fungal senescence. Annu Rev Genet. 26: 351–372.
Osiewacz HD (1997). Genetic regulation of aging. JMol Med. 75: 715–727.
Osiewacz HD, Kimpel E (1999). Mitochondrial-nuclear interactions and lifespan control in fungi. Exp Gerontol. 34: 901–909.
Bertrand H (2000). Role of mitochondrial DNA in the senescence and hypovirulence of fungi and potential for plant disease control. Annu Rev Phytopathol. 38: 397–422.
Osiewacz HD, Borghouts C (2000). Mitochondrial oxidative stress and aging in the filamentous fungus Podospora anserina. Ann NYAcad Sci. 908: 31–39.
Osiewacz HD (2002). Mitochondrial functions and aging. Gene 286: 65–71.
Osiewacz HD (2002). Aging in fungi: role of mitochondria in Podospora anserina. Mech Ageing Dev. 123: 755–764.
Osiewacz HD (2002). Genes, mitochondria and aging in filamentous fungi. Ageing Res Rev. 28: 1–18.
Osiewacz HD, Scheckhuber CQ (2002). Senescence in Podospora anserina. In: Osiewacz HD, ed. Molecular Biology of Fungal Development. New York, Basel: Marcel Dekker, pp. 87–108.
Delay C (1963). Observations inframicroscopiques sur le mycelium “senescent” du Podospora anserina. CR Acad Sci Paris 256: 4721–4724.
Silliker ME, Liotta MR, Cummings DJ (1996). Elimination of mitochondrial mutations by sexual reproduction: two Podospora anserina mitochondrial mutants yield only wildtype progeny when mated. Curr Genet. 30: 318–324.
Silliker ME, Monroe JA, Jorden MA (1997). Evaluation of the efficiency of sexual reproduction in restoring Podospora anserina mitochondrial DNA to wild-type. Curr Genet. 32: 281–286.
Marcou D, Schecroun J (1959). La senescence chez Podospora pourrait etre due a des particles cytoplasmatiques infectantes. CR Acad Sci. 248: 280–283.
Rizet G (1957). Les modifications qui conduisent a la senescence chez Podospora sontelles de nature cytoplasmique. CR Acad Sci. 244: 663–665.
Tudzynski P, Esser K (1979). Chromosomal and extrachromosomal control of senescence in the ascomycete Podospora anserina. Mol Gen Genet. 173: 71–84.
Esser K, Tudzynski P (1977). Prevention of senescence in the ascomycete Podospora anserina by the antibiotic tiamulin. Nature 265: 454–456.
Tudzynski P, Esser K (1977). Inhibitors of mitochondrial function prevent senescence in the ascomycete Podospora anserina. Mol Gen Genet. 153: 111–113.
Koll F, Begel O, Keller AM, Vierny C, Belcour L (1984). Ethidium bromide rejuvenation of senescent cultures of Podospora anserina: loss of senescence-specific DNA and recovery of normal mitochondrial DNA. Curr Genet. 8: 127–134.
Smith JL, Rubenstein I (1973). Cytoplasmic inheritance of the timing of ``senescence’’ in Podospora anserina. J Gen Microbiol. 76: 297–304.
Smith JR, Rubenstein I (1973). The development of `senescence’ in Podospora anserina. J Gen Microbiol. 76: 283–296.
Esser K, Keller W (1976). Genes inhibiting senescence in the ascomycete Podospora anserina. Mol Gen Genet. 144: 107–110.
Stahl U, Lemke PA, Tudzynski P, Kück U, Esser K (1978). Evidence for plasmid like DNA in a filamentous fungus, the ascomycete Podospora anserina. Mol Gen Genet. 162: 341–343.
Cummings DJ, Belcour L, Grandchamp C (1979). Mitochondrial DNA from Podospora anserina. II. Properties of mutant DNA and multimeric circular DNA from senescent cultures. Mol Gen Genet. 171: 239–250.
Belcour L, Begel O, Mosse MO, Vierny-Jamet C (1981). Mitochondrial DNA amplification in senescent cultures of Podospora anserina: variability between the retained, amplified sequences. Curr Genet. 3: 13–21.
Kück U, Stahl U, Esser K (1981). Plasmid-like DNA is part of mitochondrial DNA in Podospora anserina. Curr Genet. 3: 151–156.
Osiewacz HD, Esser K (1984). The mitochondrial plasmid of Podospora anserina: A mobile intron of a mitochondrial gene. Curr Genet. 8: 299–305.
Cummings DJ, McNally KL, Domenico JM, Matsuura ET (1990). The complete DNA sequence of the mitochondrial genome of Podospora anserina. Curr Genet. 17: 375–402.
Kück U, Osiewacz HD, Schmidt U, et al. (1985). The onset of senescence is affected by DNA rearrangements of a discontinuous mitochondrial gene in Podospora anserina. Curr Genet. 9: 373–382.
Jamet-Vierny C, Boulay J, Begel O, Silar P (1997). Contribution of various classes of defective mitochondrial DNA molecules to senescence in Podospora anserina. Curr Genet. 31: 171–178.
Jamet-Vierny C, Boulay J, Briand JF (1997). Intramolecular cross-overs generate deleted mitochondrial DNA molecules in Podospora anserina. Curr Genet. 31: 162–170.
Sellem CH, Lecellier G, Belcour L (1993). Transposition of a group II intron. Nature 366: 176–178.
Borghouts C, Kerschner S, Osiewacz HD (2000). Copper-dependence of mitochondrial DNA rearrangements in Podospora anserina. Curr Genet. 37: 268–275.
Michel F, Lang BF l1985). Mitochondrial class II introns encode proteins related to the reverse transcriptases of retroviruses. Nature 316: 641–643.
Fassbender S, Bruhl KH, Ciriacy M, Kück U (1994). Reverse transcriptase activity of an intron encoded polypeptide. EMBO J. 13: 2075–2083.
Vierny-Jamet C, Keller AM, Begel O, Belcour L(1982). A sequence of mitochondrial DNA is associated with the onset of senescence in a fungus. Nature 297: 157–159.
Schulte E, Kück U, Esser K (1988). Extrachromosomal mutants from Podospora anserina: permanent vegetative growth in spite of multiple recombination events in the mitochondrial genome. Mol Gen Genet. 211: 342–349.
Begel O, Boulay J, Albert B, Dufour E, Sainsard-Chanet A (1999). Mitochondrial group II introns, cytochrome c oxidase, and senescence in Podospora anserina. Mol Cell Biol. 19: 4093–4100.
Osiewacz HD, Hermanns J, Marcou D, Triffi M, Esser K (1989). Mitochondrial DNA rearrangements are correlated with a delayed amplification of the mobile intron lplDNA) in a long-lived mutant of Podospora anserina. Mutat Res. 219: 9–15.
Hermanns J, Osiewacz HD (1992). The linear mitochondrial plasmid pAL2–1 of a longlived Podospora anserina mutant is an invertron encoding a DNA and RNA polymerase. Curr Genet. 22: 491–500.
Hermanns J, Asseburg A, Osiewacz HD (1994). Evidence for a life span-prolonging effect of a linear plasmid in a longevity mutant of Podospora anserina. Mol Gen Genet. 243: 297–307.
Hermanns J, Osiewacz HD (1994). Three mitochondrial unassigned open reading frames of Podospora anserina represent remnants of a viral-type RNA polymerase gene. Curr Genet. 25: 150–157.
Hermanns J, Debets F, Hoekstra R, Osiewacz HD (1995). A novel family of linear plasmids with homology to plasmid pAL2–1 of Podospora anserina. Mol Gen Genet. 246: 638–647.
Hermanns J, Osiewacz HD (1996). Induction of longevity by cytoplasmic transfer of a linear plasmid in Podospora anserina. Curr Genet. 29: 250–256.
Prillinger H, Esser K (1977). The phenoloxidases of the ascomycete Podospora anserina. XIII. Action and interaction of genes controlling the formation of laccase. Mol Gen Genet. 156: 333–345.
Marbach K, Fernandez-Larrea J, Stahl U (1994). Reversion of a long-living, undifferentiated mutant of Podospora anserina by copper. Curr Genet. 26: 184–186.
Borghouts C, Kimpel E, Osiewacz HD (1997). Mitochondrial DNA rearrangements of Podospora anserina are under the control of the nuclear gene grisea. Proc Natl Acad Sci USA 94: 10768–10773.
Silar P, Koll F, Rossignol M (1997). Cytosolic ribosomal mutations that abolish accumulation of circular intron in the mitochondria without preventing senescence of Podospora anserina. Genetics 145: 697–705.
Osiewacz HD, Nuber U (1996). GRISEA, a putative copper-activated transcription factor from Podospora anserina involved in differentiation and senescence. Mol Gen Genet. 252: 115–124.
Borghouts C, Osiewacz HD (1998). GRISEA, a copper-modulated transcription factor from Podospora anserina involved in senescence and morphogenesis, is an ortholog of MAC1 in Saccharomyces cerevisiae. Mol Gen Genet. 260: 492–502.
Kimpel E, Osiewacz HD (1999) PaGrgl, a glucose-repressible gene of Podospora anserina that is differentially expressed during lifespan. Curr Genet. 35: 557–563.
Borghouts C, Scheckhuber CQ, Werner A, Osiewacz HD (2002). Respiration, copper availability and SOD activityin P. anserina strains with different lifespan. Biogerontology 3: 143–153.
Borghouts C, Scheckhuber CQ, Stephan O, Osiewacz HD (2002). Copper homeostasis and aging in the fungal model system Podospora anserina: differential expression of PaCtr3 encoding a copper transporter. 1nt JBiochem Cell Biol. 34: 1355–1371.
Glerum DM, Shtanko A, Tzagoloff A, Gorman N, Sinclair PR (1996). Cloning and identification of HEM 14, the yeast gene for mitochondrial protoporphyrinogen oxidase. Yeast 12: 1421–1425.
Hiser L, Di Valentin M, Hamer AG, Hosler JP (2000). Cox11p is required for stable formation of the CulB) and magnesium centers of cytochrome c oxidase. J Biol Chem. 275: 619–623.
Lode A, Kuschel M, Paret C, Rodel G (2000). Mitochondrial copper metabolism in yeast: interaction between Sco1p and Cox2p. FEBS Lett. 485: 19–24.
Liao X-B, Clare J, Farabaugh P (1987). The upstream activation site of a Ty2 element of yeast is necessary but not sufficient to promote maximal transcription of the element. Proc Natl Acad Sci USA 84: 8520–8524.
Liao X, Butow RA (1993). RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus. Cell 72: 61–71.
Sekito T, Thornton J, Butow RA (2000). Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p. Mol Biol Cell. 11: 2103–2115.
Dufour E, Boulay J, Rincheval V, Sainsard-Chanet A (2000). A causal link between respiration and senescence in Podospora anserina. Proc Natl Acad Sci USA 97: 4138–4143.
Wagner AM, Moore AL (1997). Structure and function of the plant alternative oxidase: its putative role in the oxygen defence mechanism. Biosci Rep. 17: 319–333.
Harman D (1956). A theory based on free radical and radiation chemistry. J Gerontol. 11: 298–300.
Harman D (1988). Free radicals in aging. Mol Cell Biochem. 84: 155–161.
Harman D (1992). Free radical theory of aging. Mutat Res. 275: 257–266.
Miquel J, de Juan E, Sevila I (1992). Oxygen-induced mitochondrial damage and aging. EXS 62: 47–57.
Beckman KB, Ames BN (1998). The free radical theory of aging matures. Physiol Rev. 78: 547–581.
Harman D (1998). Aging and oxidative stress. J1nt Fed Clin Chem. 10: 24–27.
Harman D (2001). Aging: overview. Ann NYAcad Sci. 928: 1–21.
Sturtz LA, Diekert K, Jensen LT, Lill R, Culotta VC (2001). A fraction of yeast Cu,Znsuperoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage. JBiol Chem. 276: 38084–38089.
Jamet-Vierny C, Contamine V, Boulay J, Zickler D, Picard M (1997). Mutations in genes encoding the mitochondrial outer membrane proteins Tom70 and Mdm10 of Podospora anserina modify the spectrum of mitochondrial DNA rearrangements associated with cellular death. Mol Cell Biol. 17: 6359–6366.
Silar P, Lalucque H, Vierny C (2001). Cell degeneration in the model system Podospora anserina. Biogerontology 2: 1–17.
Averbeck NB, Jensen ON, Mann M, Schägger H, Osiewacz HD (2000). Identification and characterization of PaMTH1, a putative o-methyltransferase accumulating during senescence of Podospora anserina cultures. Curr Genet. 37: 200–208.
Averbeck NB, Borghouts C, Hamann A, Specke V, Osiewacz HD (2001). Molecular control of copper homeostasis in filamentous fungi: increased expression of a metal- lothionein gene during aging of Podospora anserina. Mol Gen Genet. 264: 604–612.
Gross SR, Hsieh TS, Levine PH l1984). Intramolecular recombination as a source of mitochondrial chromosome heteromorphism in Neurospora. Cell 38: 233–239.
Almasan A, Mishra NC (1988). Molecular characterization of the mitochondrial DNA of a stopper mutant ER-3 of Neurospora crassa. Genetics 120: 935–945.
Kempken F, Hermanns J, Osiewacz HD (1992). Evolution of linear plasmids. J Mol Evol. 35: 502–513.
Meinhardt F, Kempken F, Kämper J, Esser K (1990). Linear plasmids among eukaryotes: fundamentals and application. Curr Genet. 17: 89–95.
Bulpitt KJ, Piko L (1984). Variation in the frequency of complex forms of mitochondrial DNA in different brain regions of senescent mice. Brain Res. 300: 41–48.
Linnane AW, Marzuki S, Ozawa T, Tanaka M (1989). Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1: 642–645.
Wallace DC (1989). Mitochondrial DNA mutations and neuromuscular disease. Trends Genet. 5: 9–13.
Linnane AW, Baumer A, Maxwell RJ, Preston H, Zhang CF, Marzuki S (1990). Mitochondrial gene mutation: the ageing process and degenerative diseases. Biochem 1nt. 22: 1067–1076.
Kadenbach B, Mu~ller-Hocker J (1990). Mutations of mitochondrial DNA and human death. Naturwissenschaften 77: 221–225.
Osiewacz HD, Hermanns J (1992). The role of mitochondrial DNA rearrangements in aging and human diseases. Aging 4: 273–286.
Wallace DC (1993). Mitochondrial diseases: genotype versus phenotype. Trends Genet. 9: 128–133.
Wallace DC (1999). Mitochondrial diseases in man and mouse. Science 283: 1482–1488.
Wallace DC (2001). A mitochondrial paradigm for degenerative diseases and ageing. Novartis Found Symp. 235: 247–263.
Liao XS, Small WC, Srere PA, Butow RA (1991). Intramitochondrial functions regulate nonmitochondrial citrate synthase lCIT2) expression in Saccharomyces cerevisiae. Mol Cell Biol. 11: 38–46.
Kirchman PA, Kim S, Lai CY, Jazwinski SM (1999). Interorganelle signaling is a determinant of longevityin Saccharomyces cerevisiae. Genetics 152: 179–90.
Lai CY, Jaruga E, Borghouts C, Jazwinski SM (2002). A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiae. Genetics 162: 73–87.
Melov S, Lithgow GJ, Fischer DR, Tedesco PM, Johnson TE (1995). Increased frequency of deletions in the mitochondrial genome with age of Caenorhabditis elegans. Nucleic Acids Res. 23: 1419–1425.
Lee SS, Lee RY, Fraser AG, Kamath RS, Ahringer J, Ruvkun G (2002). A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet. 33: 40–48.
Kirkwood TB, Holliday R (1979). The evolution of ageing and longevity. Proc R Soc Lond B Biol Sci. 205: 531–546.
Kirkwood TB (2002). Evolution of ageing. Mech Ageing Dev. 123: 737–745.
Martin GM, Austad SN, Johnson TE (1996). Genetic analysis of ageing: role of oxidative damage and environmental stresses. Nat Genet. 13: 25–34.
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Osiewacz, H.D. (2003). Aging and Longevity in the Filamentous Fungus Podospora anserina . In: Osiewacz, H.D. (eds) Aging of Organisms. Biology of Aging and its Modulation, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0671-1_2
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