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Relationships between chemical characteristics and anticoagulant activity of low molecular weight fucans from marine algae

  • Chapter
Bioactive Carbohydrate Polymers

Part of the book series: Proceedings of the Phythochemical Society of Europe ((PPSE,volume 44))

Abstract

Anticoagulant activity of fucans is closely linked to their chemical composition. The anticoagulant properties of various fractions extracted from different algae species were studied to assess the relationship between fucan structure and activity. For this purpose, cell walls were isolated from the brown algae and then submitted to sequential chemical extraction leading to high molecular weight fucans (HMWF). Different low molecular weight fucans (LMWF) were obtained by acidic degradation or radical process depolymerization of HMWF. Part of them were fractionated according to their molecular weight and charge density. We have demonstrated that the anticoagulant activity mainly correlated to the sulfate groups content and to the molecular weight distribution. The best results were obtained with fractions extracted from Ascophyllum nodosum. The anticoagulant and antithrombotic activities of each fraction were studied in vitro, ex vivo and in vivo. Affinity chromatography on stationary phase coupled with heparin binding plasma proteinase inhibitors was påerformed on the most active fractions. The high affinity fragments were purified and identified mostly sas α (1,2) and α (1,3 )linked units of 4-sulphuryl-fucose with sulfate or some branching at position 2 or 3.

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Authors and Affiliations

  1. Unité de Recherches Marines n°2, CNRS-IFREMER, France

    F. Chaubet, L. Chevolot, J. Jozefonvicz, P. Durand & C. Boisson-Vidal

  2. Laboratoire de Recherches sur les Macromolécules, CNRS, UMR 7540, Institut Galilée, Université Paris-Nord, Av. J.B. Clément, 93430, Villetaneuse, France

    F. Chaubet, J. Jozefonvicz & C. Boisson-Vidal

  3. Laboratoire de Biochimie et Molécules Marines, IFREMER, B.P. 1105, Rue de l’lle d’Yeu, 44311, Nantes cedex, France

    L. Chevolot & P. Durand

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  1. School of Pharmacy, University of Oslo, Oslo, Norway

    Berit S. Paulsen

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Chaubet, F., Chevolot, L., Jozefonvicz, J., Durand, P., Boisson-Vidal, C. (2000). Relationships between chemical characteristics and anticoagulant activity of low molecular weight fucans from marine algae. In: Paulsen, B.S. (eds) Bioactive Carbohydrate Polymers. Proceedings of the Phythochemical Society of Europe, vol 44. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9572-8_6

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