Abstract
Sodium ascorbate (SA) is oxidized in aqueous solutions by reaction with the dissolved oxygen and this process is accelerated by the presence of light (photochemical oxidation). In the present study we employed a novel system based on the combination of dehydration-rehydration liposomes, cyclodextrins and sunscreen agents in order to improve the stability of the drug. Analysis of various formulations revealed that a DRV liposomal formulation containing the α-cyclodextrin inclusion complex of the vitamin and incorporating the water soluble light absorber sulisobenzone and the lipid soluble light absorber oil red O provided maximum protection, increasing the half-life of SA from 56 min to 112.13 h.
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References
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© 1996 Springer Science+Business Media Dordrecht
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Loukas, Y.L., Vraka, V., Gregoriadis, G. (1996). Drugs in Cyclodextrins in Liposomes: A Novel Approach to Drug Stability Against Photochemical Oxidation.. In: Szejtli, J., Szente, L. (eds) Proceedings of the Eighth International Symposium on Cyclodextrins. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5448-2_103
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DOI: https://doi.org/10.1007/978-94-011-5448-2_103
Publisher Name: Springer, Dordrecht
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