Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin have been used to treat various ailments for over 100 years. As a class, these drugs are anti-inflammatory, analgesic and anti-pyretic, and they are widely used to treat chronic inflammatory diseases such as arthritis. The commercially available NSAIDs are approximately equivalent in terms of anti-inflammatory efficacy. All of the NSAIDs, however, also cause adverse effects in a significant fraction of people who consume them, and these side-effects frequently limit therapy. The most common side-effects associated with NSAID therapy are gastrointestinal (GI), with haemorrhage and frank ulceration seen in some patients; these lesions apparently can lead to increased morbidity in long-term NSAID users1. Renal and CNS effects are also observed. Because of these problems, a major goal of the pharmaceutical industry is the development of drugs that possess anti-inflammatory activity but lack the toxic effects associated with current NSAIDs. To date, no NSAIDs with the desired therapeutic profile have been commercially developed.
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© 1998 Springer Science+Business Media Dordrecht
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Isakson, P. et al. (1998). Specific COX-2 inhibitors: from bench to bedside. In: Vane, J., Botting, J. (eds) Selective COX-2 Inhibitors. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4872-6_13
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DOI: https://doi.org/10.1007/978-94-011-4872-6_13
Publisher Name: Springer, Dordrecht
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